Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1995-04-10
1999-01-26
Hendricks, Keith D.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435168, 435196, A61K 3846, C12P 300, C12N 916
Patent
active
058635335
ABSTRACT:
A nucleotide sequence encoding phytase has been isolated and cloned. The coding sequence has been inserted into an expression construct which in turn has been inserted into a vector capable of transforming a microbial expression host. The transformed microbial hosts may be used to economically produce phytase on an industrial scale. The phytase produced via the present invention may be used in a variety of processes requiring the conversion of phytate to inositol and inorganic phosphate.
REFERENCES:
patent: 3297548 (1967-01-01), Ware et al.
Graf, E. ed., Phytic Acid: Chemistry and Applications (1986) Pilatus Press, Minneapolis, MN, Chapter 2, pp. 23-42.
Powar et al., "Purification and Properties of Phytate-Specific Phosphatase from Bacillus subtilis" J. Bacteriol. (1982) 151:1102-1108.
Cosgrove, "Inositol Phosphate Phosphatases of Microbiological Origin. Inositol Phosphate Intermediates in the Dephosphorylation of the Hexaphosphates of Myo-Inositol, Scyllo-Inositol, and D-Chiro-Inositol by a Bacterial (Pseudomonas Sp.) Phytase" Aust. J. Biol. Sci. (1970) 23:1207-20.
Nayini et al., "The Phytase of Yeast" Lebensmittel Wissenschaft und Technologie (1984) 17:24-26.
Yamada et al., "Phytase from Aspergillus terreus" Agr. Biol. Chem. (1968) 32(10):1275-1282.
Nelson et al., "Effect of Supplemental Phytase on the Utilization of Phytate Phosphorus by Chicks" J. Nutrition (1971) 101:1289-1294.
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Product Information Brochure published by Alko Ltd., entitled "Finase.TM. Enzymes by Alko" Rajamaki, Finland, 4 pages total, date not available.
Ullah, "Production, Rapid Purification and Catalytic Characterization of Extracellular Phytase from Aspergillus Ficuum" Preparative Biochem. (1988) 18(4):443-458.
Ullah, Enzyme and Engineering Conference IX, Oct. 4-8, 1987, Santa Barbara, CA (poster presentation) 2 pages total.
Ullah, "Aspergillus Ficuum Phytase: Partial Primary Structure, Substrate Selectivity, and Kinetic Characterization" Preparatory Biochem. (1988) 18(4):459-471.
Ullah et al., "Extracellular Phytase (E.C. 3.1.3.8) from Aspergillus Ficuum NRRL 3135: Purification and Characterization" Preparative Biochem. (1987) 17(1):63-91.
Mullaney et al., Filamentous Fungi Conference (Apr. 1987) Pacific Grove, CA (poster presentation) 15 pages total.
Luiten Rudolf G.M.
Selten Gerardus C.M.
Van Gorcom Robert F.M.
Van Hartingsveldt Willem
Van Paridon Petrus Andreas
Gist-brocades, N.V.
Hendricks Keith D.
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