Cloning and expression of HTLV-III DNA

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

53038835, 435 693, 435 7021, 435 701, 435326, 435339, 4353391, 4241481, 4241601, C07K 1608, C07K 1610, C12P 2108, C12N 524

Patent

active

060019778

ABSTRACT:
The determination of the nucleotide sequence of HTLV-III DNA; identification, isolation and expression of HTLV-III sequences which encode immunoreactive polypeptides by recombinant,DNA methods and production of viral RNA are disclosed. Such polypeptides can be employed in immunoassays to detect HTLV-III.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo
patent: 4689398 (1987-08-01), Wu
patent: 4708818 (1987-11-01), Montagnier
patent: 4716102 (1987-12-01), Levy
patent: 4725669 (1988-02-01), Essex
patent: 5135864 (1992-08-01), Montagnier
Anilonis, A., et al., Structure of thr glycoprotein gene in rabies virus. Nature 294: 275-278 (1981).
Arya, S.K., et al., Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses. Science 225:927-929 (1984).
Ghrayeb, J., et al., Secretion cloning vectors in Escherichia coli, EMBO J., 3:2437-2442 (1984).
Gray, M.R., et al, Open reading frame cloning: Identification, cloning, and expression of open reading frame DNA, Proc. Nat'l Acad. Sci. USA 79: 6598-6602 (1982).
Hahn, B.H., et al. Molecular cloning and characterization of the HTLV-III virus associated with AIDS. Nature 312:166-169 (1984).
Kalyanaraman, V.S., et al., Antibodies to the core protein of lymphadenopathy associated virus (LAV) in patients with AIDS. Science 225:321-323 (1984).
Kiyokawa, T., et al., Envelope proteins of human T-cell leukemia virus. Proc.Nat'l.Acad.Sci.USA 81 6202-6206 (1984).
Montagnier, L., et al., Adaptation of Lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines. Science, 225: 63-66 (1984).
Ratner, L., et al. Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 313:277-284 (1985).
Ruther, U., et al., Easy identification of cDNA clones, EMBO J., 2:1791-1794 (1983).
Safai, B., et al., Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. The Lancet, 1438-1440 (1984).
Sarngadharan, M.G., et al., Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 224:506-508 (1984).
Schupbach, J., et al., Serological Analysis of a subgroup of human T-Lymphotropic retroviruses (HTLV-III) associated with AIDS. Science 224:503-505 (1984).
Seiki, M., et al., Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Nat'l Acad Sci USA 80: 3618-22 (1983).
Shaw, G.M., et al. Molecular characterization of human T-cell leukemia (lymphotropic) virus type III in the acquired immune deficiency syndrome. Science 226: 1165-1171 (1984).
Suggs, S.V., et al., Use of synthetic oligonucleotides as hybridization probes: Isolation of cloned cDNA sequences for human .beta..sub.2 -microglobulin. Proc Nat'l Acad Sci USA 78:6613-17 (1981).
Weinstock, G.M., et al., Open reading frame expression vectors: A general method for antigen production in Escherichia coli using protein fusions to .beta.-galactosidase. Proc Nat'l Acad Sci USA 80: 4432-36 (1983).
Chang et al. Science v228 p93-996, Apr. 1, 1985.
Robey et al Science vol. 228 p593-595,May 3, 1985.
Montagnier et al Human T-Cell Leukemia Lymphoma Virus Cold Spring Harbor p 363-379, Jan 1, 1984.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Cloning and expression of HTLV-III DNA does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cloning and expression of HTLV-III DNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning and expression of HTLV-III DNA will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-864660

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.