Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1992-06-23
2000-04-25
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4242041, 435 693, 435 697, 530350, 530395, 530403, A61K 3912, C07K 1401
Patent
active
060541261
ABSTRACT:
This invention relates to the cloning and characterization of the infectious bursal disease virus (IBDV) genome, to the identification of cloned genes for host-protective antigens of IBDV, to the expression of cDNA inserts encoding the whole or part of host-protective antigens of IBDV in E.coli or other host cells, and to the use of the expressed antigens in the production of virus neutralizing antibodies in chickens. The invention also relates to the production of an effective sub-unit vaccine against IBDV utilizing the expressed antigens, as well as to the use of the expressed antigens in diagnostic tests, assays and the like.
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Hudson, L. et al. Practical Immunology (1980). pp. 8-9. Blackwell Sci. Publications.
Jackwood, D.J. et al. Avian Dis. 28:990-1006 (1984) Nucleic Acid and Structural Proteins of I.B.D.V. Isolaters Belonging to Serotypes I and II.
MacReadie I.G. et al. Vaccine 8:549-552 (1990) "Passive Protection Against I.B.D.V. by Viral VP2 Expressed in Yeast.".
Becht, H. Curr. Top. Microbiol. Immunol. 90:107-121 (1980), "Infectious Bursal Virus Disease".
Dobos, P. J. Virology 32:1046-50 (1979), "Peptide Map Comparison of the Proteins of I.B.D.V.".
Fahey, K.J. et al. J. Gen. Virol. 66:1479-88 (1985) "Characterization by Western Blotting of the Immunogens of I.B.D.V.".
Fahey, K.J. et al. J. Gen. Virol. 66:2693-2702 (1985) "Antibody to the 32K Structural Protein of I.B.D.V. Neutralizes Viral Infectivity in Vitro and Confers Protection on Young Chickens.".
Muller, et al. J. Virology 44:384-92 (1982) Biosynthesis of Virus-Specific Protein in Cells Infected with I.B.D.V. and their Significance as Structural Elements for Infectious Virus and Incomplete Particles.
Azad Ahmed Abdullah
Fahey Kevin John
Hudson Peter John
Commonwealth Scientific and Industrial Research Organization
Cunningham Thomas M.
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