Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-06-21
1998-05-12
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4352523, 435325, 536 235, 530350, 935 9, C07K 1472, C12N 1512, C12N 1563, C07H 2104
Patent
active
057503664
ABSTRACT:
The present invention relates to the GnRH-R genes and proteins. The DNA sequences disclosed herein may be engineered into expression systems designed for the production of GnRH-R and/or cell lines which express the GnRH-R and preferably respond to GnRH induced signal transduction. Such cell lines may advantageously be used for screening and identifying GnRH agonists and antagonists. In accordance with another aspect of the invention, the GnRH DNA, antisense oligonucleotide sequences, the GnRH expression products, and antibodies to such products may be used in the diagnosis and therapy of reproductive disorders associated with abnormal expression of the GnRH-R; e.g., overexpression, underexpression or expression of a dysfunctional mutant receptor. Transgenic animals containing the GnRHR transgene may be used as animal models for the evaluation of GnRH analogs in vivo.
REFERENCES:
Clayton, 1987, "Gonadotrophin Releasing Hormone: from Physiology to Pharmlogy," Clinical Endocrinology 26:361-384.
Clayton, 1989, "Gonadotrophin-Releasing Hormone: its Actions and Receptors," Journal of Endocrinology 120:11-19.
Sealfon et al., 1990, "Gonadotropin-Releasing Hormone Receptor Expression in Xenopus Oocytes," Molecular Endocrinology 4:119-124.
Probst et al., 1992, "Sequence Alignment of the G-Protein Coupled Receptor Superfamily," DNA and Cell Biology 11:1-20.
Tsutsumi et al., 1992, "Cloning and Functional Expression of a Mouse Gonadotropin-Releasing Hormone Receptor," Molecular Endocrinology 6(7):1163-1169.
Eidne et al., 1992, "Molecular Cloning and Characterization of the Rat Pituitary Gonadotropin-Releasing Hormone (GnRH) Receptor," Molecular and Cellular Endocrinology 90:R5-R9, Oct.
Kakar et al., 1992, "Cloning, Sequencing and Expression of Human Gonadotropin Releasing Hormone (GnRH) Receptor," Biochemical and Biophysical Research Communications 189(1):289-295, Nov.
Chi et al., 1993, "Cloning and Characterization of the Human GnRH Receptor," Molecular and Cellular Endocrinology 91:R1-R6.
Mount Sinai School Of Medicine Of The City University Of New Yor
Spector Lorraine M.
Walsh Stephen
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