Cloning and expression of a variant gene of platelet factor 4 an

Details Cloning and expression of a variant gene of platelet factor 4 an Cloning and expression of a variant gene of platelet factor 4 an

1992-11-09

1994-05-31

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530380, 530829, 530324, 435 691, 435 697, 43525233, A61K 3700, C07K 1300, C07K 1508, C12N 1512

Patent

active

053170113

ABSTRACT:
The present invention provides for the purification from native sources or the cloning and expression of a variant form of platelet factor 4 and also provides recombinant DNA vectors and methods for the expression and recovery of the platelet factor 4 variant. Also provided are compositions and methods for modulating immune responses in mammals comprising immunomodulating effective amounts of platelet factor 4 variant.

REFERENCES:
Green, C. J. et al., The Journal of Cell Biology 107 (6 part 3) 309A, Abstract 1743 (1988).
Poncz, M. et al. Clinical Research 36(3):568A (1988).

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