Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-02
2000-06-20
Caputa, Anthony C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 435325, 530350, 536 237, C12P 2106, C12N 120, C12N 1500, C07H 2104
Patent
active
060776900
ABSTRACT:
An isolated DNA molecule encoding a protein comprising all or a portion of a 54 kDa protein of Toxoplasma gondii is disclosed. The protein is capable of reacting with antibodies present in the sera or other biological samples of humans or animals infected with T. gondii. A vector comprising the DNA molecule, a host cell transformed with the vector, and a method for recombinantly producing the protein are disclosed.
REFERENCES:
patent: 4877726 (1989-10-01), Suzuki et al.
patent: 4879213 (1989-11-01), Fox et al.
R. Saveedre et al., "Human T cell clone identifies a potentially protective 54-kDa protein antigen of Toxoplasma gondii cloned and expressed in Escherichia coli", Journal of Immunology, vol. 147, No. 6, (Sep. 1991).
Prince et al., "Cloning of cDNAs encoding a 28 kilodalton antigen of Toxoplasma gondii", Molecular and Biochemical Parasitology, 34, 3-14 (1989).
R. Sveedra et al., "Monoclonal antibodies identify new Toxoplasma gondii soluble antigens", Hybridoma, vol. 5, No. 5, pp. 453-463 (Oct. 1990).
Burg et al., "Molecular Analusis of the Gene Encoding the Major Surface Antigen of Toxoplasma gongii", The Journal of Immunology, vol. 141, No. 10, 1988, pp. 3584-3591.
Burgess et al., "Possible Dissociation of the Heparin-Binding and Nitrogen Actimates of Heparin-Binding Growth Factor from its Receptor-Binding Activities by Sets-Diasted Mytogensis of a Single Lysine Residues", The Journal of Cell Biology, vol. 111, 1990, pp. 2129-2138.
Lazar et al., "Transforming Growth Factor Mutation of Adaptive Acid 47 and Lusins 48 Result in Different Biological Activities", Molecular and Cell Biology, vol. 8, No. 1, 1988, pp. 1247-1252.
Bowie et al., "Deciphering the Message in Protein Sequence: Tolerance to Amino Acid Substitution," Science, vol. 247, pp. 1306-1310.
Sallgaller et al. Cancer Immunol. Immuno. 39:105-116, 1994.
Herion Pascal
Saavedra-Duran Rafael
Caputa Anthony C.
Navarro Mark
LandOfFree
Cloning and expression of a protein antigen of Toxoplasma gondii does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloning and expression of a protein antigen of Toxoplasma gondii, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning and expression of a protein antigen of Toxoplasma gondii will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1850960