Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-10-07
1999-07-27
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, C07H 2104
Patent
active
059292237
ABSTRACT:
A method of regulating long term memory is disclosed. Also disclosed is isolated DNA encoding a cyclic 3',5'-adenosine monophosphate responsive transcriptional activator, isolated DNA encoding an antagonist of cyclic 3',5'-adenosine monophosphate-inducible transcription, isolated DNA encoding an enhancer-specific activator, and isolated DNA encoding a nitric oxide synthase.
REFERENCES:
Walton et al. (1992) A dominant repressor of cyclic adenosine 3', 5'-monophosphate (cAMP)-regulated enhancer-binding protein acticity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo. Mol. Endocrinol. 6:647-655, 1992.
Bourtchuladze et al. (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79:59-68, Oct. 1994.
Abel et al., Genes & Development, 6:466-480 (1992).
Usui, Takeshi, et al., "Isolation of Drosophila CREB-B: A Novel CRE-Binding Protein," DNA and Cell Biology, 12(7): 589-595 (1993).
Drain, Peter et al., "cAMP-Dependent Protein Kinase and the Disruption of Learning in Transgenic Flies,", Neuron, 6:71-82 (1991).
Skoulakis, Efthimios M.C. et al., "Preferential Expression in Mushroom Bodies of the Catalytic Subunit of Protein Kinase A and Its Role in Learning and Memory," Neuron, 11:197-208 (1993).
Davis, Hasker P. and Squire, Larry R., "Protein Synthesis and Memory: A Review," Psychological Bulletin, 96(3):518-559 (1984).
Gerber, Hans-Peter et al., "Transcriptional Activation Modulated by Homopolymeric Glutamine and Proline Stretches," Science, 263:808-811 (1994).
Grove, J. Russell et al., "Recombinant Fragment of Protein Kinase Inhibitor Blocks Cyclic AMP-Dependent Gene Transcription," Science, 238:530-533 (1987).
Foulkes, Nicholas S. and Sassone-Corsi, Paolo, "More is Better" Activators and Repressors from the Same Gene, Cell, 68:411-414 (1992).
Foulkes, Nicholas S. et al., "Developmental switch of CREM function during spermatogenesis: from antagonist to activator," Nature, 355:80-83 (1992).
Foulkes, Nicholas S. et al., "CREM Gene: Use of Alternative DNA-Binding Domains Generates Multiple Antagonists of cAMP-Induced Transcription," Cell, 64:739-749 (1991).
de Groot, Rolf P. and Sassone-Corsi Paolo, "Hormonal Control of Gene Expression: Multiplicity and Versatility of Cyclic Adenosine 3', 5'-Monophosphate-Responsive Nuclear Regulators," Molecular Endocrinology, 7(2):145-153 (1993).
Habener, Joel F., "Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors," Molecular Endocrinology, 4(8):1087-1094 (1990).
Huang, Yan-You and Kandel, Eric R., "Recruitment of Long-lasting and Protein Kinase A-dependent Long-term Potentiation in the CA1 Region of Hippocampus Requires Repeated Tetanization," Learning & Memory, 1:74-82 (1994).
Frey, U. et al., "Effects of cAMP Simulate a Late Stage of LTP i Hippocampal CA1 Neurons," Science, 260:1661-1664 (1993).
Kaang, Bong-Kiun et al., "Activation of cAMP-Responsive Genes by Stimuli That Produce Long-Term Facilitation in Aplysia Sensory Neurons," Neuron, 10:427-435 (1993).
Dash, Pramod K. et al., "Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons block long-term facilitation," Nature, 345:718-721 (1990).
Alberini, Cristina, M. et al., "C/EBP Is an Immediate-Early Gene Required for the Consolidation of Long-Term Facilitation in Aplysia," Cell, 76:1099-1114 (1994).
Schacher, S. et al., "cAMP Evokes Long-term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis," Science, 240:1667-1669 (1988).
Montarolo, P. G. et al., "A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia," Science, 234:1249-1254 (1986).
Chrivia, John C. et al., "Phosphorylated CREB binds specifically to the nuclear protein CBP," Nature, 365:855-859 (1993).
Mellon, Pamela L. et al., "Regulation of transcription by cyclic AMP-dependent protein kinase," Proc. Natl. Acad. Sci. USA, 86:4887-4891 (1989).
Delmas, Veronique et al., "Alternative usage of initiation codons in mRNA encoding the cAMP-responsive-element modulator generates regulators with opposite functions," Proc. Natl. Acad. Sci. USA, 89:4226-4230 (1992).
Ruppert, Siegfried et al., "Multiple mRNA isoforms of the transcrition activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes," The EMBO Journal, 11(4):1503-1512 (1992).
Rehfuss, Robert P. et al., "The cAMP-regulated Enhancer-binding Protein ATF-1 Activates Transcription in Response to cAMP-dependent Protein Kinase A," J. Biol. Chem., 266(28):18431-18434 (1991).
Liu, Fang et al., "Activating Transcription Factor-1 Can Mediate Ca.sup.2+ -and cAMP-inducible Transcriptional Activation," J. Biol. Chem., 268(9):6714-6720 (1993).
Deutsch, Paul J. et al., "Structural Determinants for Transcriptional Activation by cAMP-responsive DNA Elements," J. Biol. Chem., 263(34):18466-18472 (1988).
Gonzalez, G.A. et al., "Characterization of Motifs Which Are Critical for Activity of the Cyclic AMP-Responsive Transcription Factor CREB," Mol. Cell. Biol., 11(3):1306-1312 (1991).
Meinkoth, Judy L. et al., "Induction of a Cyclic AMP-Responsive Gene in Living Cells Require the Nuclear Factor CREB," Mol. Cell. Biol., 11(3):1759-1764 (1991).
Huang, Paul L. et al., "Targeted Disruption of the Neuronal Nitric Oxide Synthase Gene," Cell, 75:1273-1286 (1993).
Schuman, Erin M. and Madison, Daniel V., "A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation," Science, 254:1503-1506 (1991).
Xie, Qiano-wen et al., "Cloning and Characterization of Inducible Nitric Oxide Synthase form Mouse Macrophages," Science, 256:225-228 (1992).
Bredt, David S. et al., "Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase," Nature, 351:714-718 (1991).
O'Dell, Thomas J. et al., "Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS," Science, 265:542-546 (1994).
Rickard, Nikki S. et al., "A Nitric Oxide Agonist Stimulates Consolidation of Long-Term Memory in the 1-Day-Old Chick," Behavioral Neuroscience, 108(3):640-644 (1994).
Holscher, Christian and Rose, Steven, P,R. "An inhibitor of nitric oxide synthesis prevents memory formation in the chick," Neuroscience Letters, 145:165-167 (1992).
Bohme, Georg Andrees et al., "Altered synaptic plasticity and memory formation in nitric oxide synthase inihibitor-treated rats," Proc. Natl. Acad. Sci. USA, 90:9191-9194 (1993).
Haley, Jane E. et al., "The Role of Nitric Oxide in Hippocampal Long-Term Potentiation," Neuron, 8:211-216 (1992).
Chapman, Paul F. et al., "Inhibition of nitric oxide synthesis impairs two different forms of learning," NeuroReport, 3(7):567-570 (1992).
Edelman, G.M. and Gally, J.A., "Nitric oxide: Linking space and time in the brain," Proc. Natl. Acad. Sci. USA, 89:11651-11652 (1992).
Bredt, David S. and Snyder, Solomon H., "Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme," Proc. Natl. Acad. Sci. USA, 87:682-685 (1990).
Rees, D.D. et al., "Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo," Br. J. Pharmacol., 101:746-752 (1990).
Tully, Tim and Quinn, William G., Classical conditioning and retention in normal and mutant Drosophila melanogaster, J. Comp Physiol A 157:263-277 (1985).
Rosenzweig, Mark R. and Bennett, Edward L. "Basic Processes and Modulatory Influences in the Stages of Memory Formation," Neurobiology of Learning and Memory, G. Lynch, J.L. McGaugh, and N. M. Weinberger eds. The Guilford Press, New York, pp.263-288 (1984).
Tully, T. et al., "Genetic Dissection of Memory Formation in Drosophila melanogaster", Cold Spring Harbor Symposia on Quantitative Biology, vol. LV:203-211, Cold Spring Harbor Laboratory Press (1990).
Yin, J. et al., "Expressionof a Dominant Negative Form of CREB Interferes with Long-Term Memory," Abstracts presented at the 1993 meeting on Neurobiology of Drosophila, Cold Spring Harbor Laboratory (1993).
Regulski, Michael and Tully, Tim "Cloning of a Drosophila Nitric Oxide Synthase," Abstracts presented at the
Regulski Michael
Tully Timothy P.
Yin Jerry Chi-Ping
Cold Spring Harbor Laboratory
Elliott George C.
Schwartzman Robert
LandOfFree
Cloning and characterizing of genes associated with long-term me does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloning and characterizing of genes associated with long-term me, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning and characterizing of genes associated with long-term me will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-879962