Cloning and characterization of the FLBA gene of H. pylori,...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C424S093400

Reexamination Certificate

active

06838273

ABSTRACT:
The present application relates to nucleotide sequences which regulate the biosynthesis of the flagella proteinsHelicobacter pylori, to the proteins encoded by these sequences and to aflagellate bacterial strains. The invention also relates to the use of these means for detecting an infection due toH.pylorior for protecting against such an infection.

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Josenhans et al., “Comparative Ultrastructural and Functional Studies ofHelicobacter pyloriandHelicobacter mustelaeFlagellin Mutants: Both Flagellin Subunits, FlaA and FlaB, Are Necessary for full Motility inHelicobacterSpecies”,J. Bacteriology, vol. 177, No. 1, Jun. 1996, pp. 3010-3020.
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Suerbaum et al., “Cloning, Sequencing and Mutagenesis of theH. pyloriflbA Gene—a Homolog of The lcrD/flbF/invA Family of Genes Associated with Motility and Virulence”,Am. J. Gastroenterol., vol. 89, No. 8, Aug. 1994, p. 1331, Article nA 185.
Suerbaum et al., “Cloning, Expression and Mutagenesis of theH. pyloriflbA Gene—a Homolog of The lcrD/flbF Family of Genes Associated with Motility and Virulence”, Abstracts of 95th General Meeting for American Society of Microbiology, May 21-25, 1995, p. 181, Article nA B-93.

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