Cloning and characterization of a cardiac adenylyl cyclase

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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4353201, 4352523, 43525233, 536 232, C12N 1500

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053345215

ABSTRACT:
A DNA sequence encoding a novel effector enzyme referred to as a cardiac adenylyl cyclase is described. The amino acid sequence of the cardiac adenylyl cyclase encoded by that DNA sequence is also described.

REFERENCES:
Pfeuffer et al., PNAS vol. 82, May 1985, pp. 3086-3090.
Mollner et al, Eur. J. Biochem, vol. 71, 1988, pp. 265-271.
Bakalyar et al, Science, vol. 250, Dec. 7, 1990, pp. 1403-1406.
Krupinski et al., Science, vol. 244, Jun. 30, 1989, pp. 1558-1564.
Pfeuffer et al., "Purification of Adenylyl Cyclase from Heart and Brain," Methods in Enzymology, vol. 195, pp. 83-91 (Academic Press, Inc., N.Y. 1991).
Gao et al., "Cloning and expression of a widely distributed (type IV) adenylyl cyclase," Proc. Natl. Acad. Sci. USA 88: 10178-10182 (1991).
Homcy et al., "Affinity purification of cardiac adenylate cyclase: Dependence on prior hydrophobic resolution," Proc. Natl. Acad. Sci. USA 75(1):59-63 (1978).
Parma et al., "Sequence of a Human Brain Adenylyl Cyclase Partial cDNA: Evidence for a consensus cyclase specific domain," Biochem. Biophys. Res. Comm. 179(1):455-462 (1991)
Feinstein et al., "Molecular cloning and characterization of a Ca.sup.2+ /calmodulin-insensitive adenylyl cyclase from rat brain," Proc. Natl. Acad. Sci. USA 88:10173-10177 (1991).
Ishikawa et al., "Isolation and Characterization of a Novel Cardiac Adenylylcyclase cDNA," J. Biol. Chem. 267(19):13553-13557 (1992).
Katsushika et al., "Cloning and characterization of a sixth adenylyl cyclase isoform: Types V and VI constitute a subgroup . . . ," Proc. Natl. Acad. Sci. USA 89:8774-8778 (1992).
Yoshimura et al., "Cloning and expression of a Ca.sup.2+ -inhibitable adenylyl cyclase from NCB-20 cells," Proc. Natl. Acad. Sci. USA 89:6716-6720 (1992).
Wayman et al., "Isolation of cDNA clones for heart adenylate cyclase," FASEB J. 6(5):A1632 (Feb. 28, 1992).

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