Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-02-16
2000-02-29
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 235, C12N 1512
Patent
active
060308109
ABSTRACT:
DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
REFERENCES:
patent: 5132296 (1992-07-01), Cherksey
patent: 5380836 (1995-01-01), Rogart
patent: 5439808 (1995-08-01), Blake et al.
Dietrich et al., J. Neurochemistry 1998, 70(6), 2262-2272.
Catterall, TINS 16(12):500-506 (1993).
Numa, et al., Annals of the New York Academy of Sciences 479:338-355 (1986).
Rogart, Cribbs, et al., Proc. Natl. Acad. Sci., 86:8170-8174 (1989).
D'Arcangelo, et al., J. Cell Biol. 122:(4)915-921 (1993).
Toledo-Aral, et al., Proc. Nat. Acad. Sci. 94:1527-1532 (1997).
Sangameswaran, et al., J. Biol. Chem. 272:14805-14809 (1997).
Auld, et al., Neuron 1:449-461 (1988).
Kayano, et al., FEBS Lett. 228:187:187-194 (1988).
Trimmer, et al., Neuron 3:33-49 (1989).
Schaller, et al., J. Neurosci. 15:3231-3242 (1995).
Sangameswaran, et al., J. Biol. Chem. 271:5953-5956 (1996).
Akopian, et al., Nature 379:257-262 (1996).
Felipe, et al., J. Biol. Chem. 269:30125-30131 (1994).
Akopian, et al., FEBS Lett. 400:183-187 (1997).
Redfern, et al., Acta Physiol. Scand. 82:70-78 (1971).
Rogart, Ann. Rev. Physiol. 43:711-725 (1981).
Roy, et al., J. Neurosci. 12:(6)2104-2111 (1992).
Ikeda, et al., J. Neurophysiol. 55:527-539 (1996).
Stea, et al., Neurosci. 47:727-736 (1992).
Burgess, et al., Nature Genetics 10:461-465 (1995).
Sills, et al., J. Clin. Invest. 84:331-336 (1989).
Ingles, et al., Society for Neuroscience 21:717.11 (1995) (Abstract only).
Moss, et al., Society for Neuroscience 19:1-3 (1993) (Abstract only).
Noda, et al., FEBS Lett. 259(1):213-216 (1989).
Beckh, FEBS Lett. 262(2):317-322 (1990).
Noda, et al., Nature 320(13):188-192 (1986).
Klugbauer, et al., EMBO Journal 14(6):1084-1090 (1995).
Rabert et al., "A Tetrodotoxin-Resistant Voltage-Gated Sodium Channel From Human Dorsal Root Ganglia, hPN3/SCN10A,"Pain 78: 107-114 (1998).
Delgado Stephen Gregory
Dietrich Paul Shartzer
Fish Linda Marie
Herman Ronald Charles
Sangameswaran Lakshmi
Clark Janet Pauline
Mohan-Peterson Sheela
Ulm John
LandOfFree
Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-681879