Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-12-12
2000-10-31
Chambers, Jasemine
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4353201, 435325, 435455, 435 691, 536 235, 536 2431, C12N 1563, C12N 1500, C12N 500
Patent
active
061400602
ABSTRACT:
Described herein is an isolated polynucleotide encoding an LPA receptor. Also described is a recombinant DNA molecule comprising a nucleic acid encoding an LPA receptor and expression controlling elements linked therewith, as well as the use of nucleic acid coding for an LPA receptor for expression to obtain a functional receptor protein and for further gene cloning to identify structurally related receptor proteins. Also described herein is LPA receptor as a product of recombinant production in a cellular host. Described is a method of utilizing the LPA receptor in a chemical screening program to identify LPA receptor ligands. The invention further describes antibodies directed to the LPA receptor for use for example in diagnosis of conditions wherein the levels of LPA are altered.
REFERENCES:
GenBank Database Sequence for bases 1-1436 from Brain Res. Mol. Brain Res. 42 (2), 245-254 (1996).
GenBank Database Sequence for bases 1552 from Brain Res. Mol. Brain Res. 42 (2), 245-254 (1996).
Hecht et al., Journal of Cell Biology, vol. 135, pp. 1071-1083, Nov. 1996.
Hecht et al., Society of Neuroscience Abstracts, vol. 21, p. 1289, Abstract No. 511.6, Nov. 1995.
Saeki et al., FEBS Letters, vol. 336, pp. 317-322, Dec. 27, 1993.
Macrae et al., Molecular Brain Research, vol. 42, pp. 245-254, 1996.
Masana et al., Receptor and Channels, vol. 3, pp. 255-262, 1995.
Chun Jerold J. M.
Hecht Jonathan H.
Chambers Jasemine
Martin Jill D.
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