Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-03-23
1991-12-03
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 71, 435 91, 4351723, 436501, 436543, 436536, 436811, 436815, 530387, 935 12, 935 14, 935 29, 935 36, 935 81, 935 88, C07H 2104, C12Q 168, G01N 33532, G01N 33564
Patent
active
050701924
ABSTRACT:
The invention relates to cDNA molecules coding for eukaryotic topoisomerase I polypeptide. The invention provides cDNA mlecules comprising a part of the cDNA sequence of topoisomerase I which encode at least one epitope for autoantibodies to eukaryotic topoisomerase I. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for eukaryotic topoisomerase I. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for eukaryotic topoisomerase I. In another embodiment, the invention provides for the detection of autoantibodies to eukaryotic topoisomerase I using the eukaryotic topoisomerase I polypeptides coded for by the cDNA molecules of the invention.
REFERENCES:
Juarez et al. (1988), Arthritis and Rheumatism, vol. 31, No. 1, pp. 108-115.
Douvas, et al. (1979), Journal of Biological Chemistry, 254:10514-10522.
Liu, et al. (1981), Proc. Nat. Acad. Sci., 78:3487-3491.
McConaughy, et al. (1981), Biochim, Biophys. Acta, 655:1-8.
Geisler, et al. (1985), Journal of Immunological Methods, 80:211-219.
Thrash, et al. (1985), Proc. Nat. Acad. Sci., 82:4374-4378.
Goto, et al. (1985), Proc. Nat. Acad. Sci., 82:7178-82.
Shero, et al. (1986), Science, 231:737-740.
Guldner, et al. (1986), Chromosoma, 94:132-138.
Maul, et al. (1986), Proc. Nat. Acad. Sci., 83:5145-5149.
Uemura, et al. (1987), Nucleic Acid Research, 15:9727-9739.
D'Arpa, et al. (1988), Proc. Nat. Acad. Sci., 85:2543-2547.
Samuels et al., "Inhibition of Topoisomerase I by Antibodies in Sera from Scleroderma Patients," FEBS 4289 (1986), 209:231-234.
Durban, et al., Biochemical and Biophysical Research Communication, 154:358-364 (1988).
D'Arpa Peter
Earnshaw William C.
Marschel Ardin H.
The Johns Hopkins University
Wax Robert A.
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