Cloned human lysophospholipase

Details Cloned human lysophospholipase Cloned human lysophospholipase

2007-11-13

2007-11-13

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C536S023200, C514S04400A

Reexamination Certificate

active

09493601

ABSTRACT:
A cloned of a human brain lysophospholipid-specific lysophospholipase enzyme molecule, its potential use for treatment of a host of diseases and method of inactivation are disclosed. Also disclosed are its distribution in tissue sand detailed kinetic analysis. hLysoPLA has a single substrate binding site and a surface recognition site. In contrast to many nonspecific lipolytic enzymes that exhibit lysophospholipase activity, hLysoPLA hydrolyzes only lysophospholipids and has no other significant enzymatic activity.

REFERENCES:
patent: 5965423 (1999-10-01), Hillman et al.
Sequence search alignment between Applicants' SEQ ID No. 1 and Accession No. AF052112.
Wang et al. [BBA 1437:157-169 (1999)].

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