Cloned human genes for muscarinic acetylcholine receptors and ce

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

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435 691, 4353201, 536 231, 536 235, 935 11, 935 70, 935 71, C12N 1585, C12N 1563, C07H 2104

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active

057473366

ABSTRACT:
Clones of human genes for a plurality of different muscarinic acetylcholine receptors and stable cell lines homogeneously expressing a specific subtype of the receptors have been prepared. A method for screening muscarinic drugs has been described.

REFERENCES:
Peralta et al. (a), EMBO Journal b(13):3923-9 (1987).
Peralta et al. (b), Science 236:600-605 (1987).
Bonner et al., Science 237:527-532 (1987).
Brann et al., Molecular Pharmacology 32: 450-5 (1987).
Chen et al., Mol. Cell. Biol. 7:2745-52 (1987).
Jones et al., Mol. Pharmacology 34: 421-426 (1988).
Allard et al, Nucleic Acids Research, vol. 15, No. 24 (1987).

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