Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-08-01
2006-08-01
Housel, James (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023720, C536S023100, C435S235100, C435S325000, C435S239000, C514S04400A, C424S189100, C424S204100, C424S228100
Reexamination Certificate
active
07084266
ABSTRACT:
The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, gentotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.
REFERENCES:
patent: 5428145 (1995-06-01), Okamoto et al.
patent: 5874565 (1999-02-01), Rice et al.
patent: 532167 (1992-07-01), None
patent: 0532 167 (1993-03-01), None
patent: WO 91/15575 (1991-10-01), None
patent: WO 00/26418 (2000-05-01), None
Yoo et al. J. Virol. 1995, vol. 69, No. 1, pp. 32-38.
Sequence conparision data sheets.
Okamoto, H. et al. “Nucleotide sequence of genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent region.” Journal of General Virology, 72 (pp. 2697-2704 ) 1991.
Han J. H. et al, “Group specific sequences and conserved secondary structure at the 3′ end of HCV genome and its implication for viral replication.” Nucleic Acids Research , Oxford University Press, 20:13. (p. 3520) Apr. 1992.
Yanagi, M. et al, “Transcripts of a chimeric cDNA clone of Hepatitis C virus genotype 1b are infectious in vivo.” Virology 244 (pp. 161-172) 1998.
Ohno, T. et al, “New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a,” Journal of Clinical Microbiology 35:1 (pp. 201-207) 1997.
Hashimoto, M. et al. “Typing six major hepatitis C virus genotypes by polymerase chain reaction using primers derived from nucleotide sequences of the NS5 region.” International Hepatology Communications 4:5 (pp. 263-267) 1996.
Yong Yuan Zhang et al, “Greater diversity of hepatitis C virus genotypes found in Hong Kong than in Mainland China.” Journal of Clinical Microbiology 33:11 (pp. 2931-2934) 1995.
Fox, S. et al., “Rapid genotyping of hepatitis C virus isolates by dideoxy fingerprinting.” Journal of Virology Methods 53:1 (pp. 1-9) May 1995.
Yanagi, M. et al, “Hepatitis C Virus: An infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras.” Virology 262 (pp. 250-263) 1999.
De Francesco, R. et al, “A zinc binding site in viral serine proteinases.” Biochemistry 35:41 (pp. 13282-13287) 1996.
Stempniak, M. et al, “The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme.” Journal of Virology 71:4 (pp. 2881-2886) 1997.
Park, Y.M. et al, “Monitoring antibody titers to recombinant core-NS3 fusion polypeptide is useful for evaluating hepatitis C virus infection and responses to interferon-alpha therapy,” J. Korean Medicine Sci. 14 (pp. 165-170) Apr. 1999.
Mison, L.M. et al. “Prevalence of hepatitis C virus and geneotype distribution in an Australian volunteer blood donor population,” Transfusion 37 (pp. 73-78) Jan. 1997.
Wright-Minogue, J. et al. “Cross-genotypic interaction between hepatitis C virus NS3 protease domains and NS4A cofactors,” Journal of Hepatology 32:3 (pp. 497-504) 2000.
Martin, J. et al. “In vitro effect of amantadine and interferon. alpha.—2a on hepatitis C virus makers in cultured peripheral blood mononuclear cells from hepatitis C virus-infected patients,” Antiviral Research 42:1 (pp. 59-70) 1999.
Urushihara, A. et al. “Changes in antibody titers to hepatitis C virus following interferon therapy for chronic infection.” Journal of Medical Virology 42:4 (pp. 348-356) 1994.
Sali, D.L. et al. “Serine protease of Hepatitis C virus expressed in insect cells as the NS3/4A complex.” Biochemistry 37:10 (pp. 3392-3401) 1998.
Calvo, P.L. et al. “Hepatitis C virus heteroduplex tracking assay for genotype determination reveals diverging Genotype 2 isolates in Italian hemodialysis patients.” J. of Clinical Microbiology 36:1 (pp. 227-233) Jan. 1998.
Bukh, J. et al. “At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide.” Proceedings of the NAS of the USA, US, NAS 90 (pp. 8234-8238) Sep. 1994.
Simmonds. P. et al. “Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS-5 regions.” J. of General Virology 75 (pp. 1053-1061) 1994.
Van Doorn, I.J., et al. “Sequence analysis of hepatitis C virus genotypes 1 to 5 reveals multiple novel subtypes in the Benelux countries.” J. of General Virology 76 (pp. 1871-1876) 1995.
Chaodong, Wu et al, “Antibody response to E2 glycoprotein induced in mice by immunization with plasmid DNA containing sequence derived from a chinese genotype III/2a isolate of hepatitis C virus.” Chinese Medical Journal 112:2 (pp. 166-168) Feb. 1999.
Yuki, N. et al. “Quantitative analysis of antibody to Hepatitis C virus Envelope 2 Glycoprotein in patients with chronic Hepatitis C virus infection.” Hepatology 23:5 (pp. 947-952) May 1996.
Longombardo, G. et al, Immune response to an epitope of the NS4 protein of Hepatitis C virus in HCV-related disorders.
Fabrizi, F. et al, “Hepatitis C virus genotypes in chronic dialysis patients.” Nephrol. Dial. Transplant. 11 (pp. 679-683) 1996.
Lin, H-H. et al. “Serotypes, genotypes and levels of Hepatitis C Viremia in pregnant women in Taiwan.” J. Formos. Medl. Assoc. 95:6 (pp. 429-434) 1996.
Devesa, M. et al, “Reduced antibody reactivity to Hepatitis C virus antigen in Hemodialysis patients coinfected with hepatits B virus.” Clinical and Diagnostic Laboratory Immunology 4:6 (pp. 639-642) Nov. 1997.
Yuki, N. et al, “Hepatitis C virus replicative levels and efficiency of genotyping by specific PCR and antibody assay.” J. of Clinical Microbiology 35:5 (pp. 1184-1189) May 1997.
Zhang, Z-X et al, “Evaluation of the multiple peptide assay for typing of antibodies to the Hepatitis C Virus: Relation to genomic typing by the Polymerase Chain Reaction.” J. of Medical Virology 45 (pp. 50-55) 1995.
Nomura, H. et al, “Interferon therapy and Hepatitis C virus.” Journal of Gastroenterology and Hepatology 14:1 (pp. 85-89) Jan. 1999.
Furusyo, N. et al, “Differences between interferon-alpha and -beta treatrment for patients with chronic hepatitis C virus infection.” Digestive Diseases and Sciences 44:3 (pp. 608-617) Mar. 1999.
Yao, G.B. et al, “Long-term efficacy of recombinant interferon alpha 2a in the treatment of chronic Hepatitis C: A randomized prospective study comparing two dose schedules in Chinese patients.” Hepato-Gastroenterology 46 (pp. 1059-1064) Apr. 1999.
Martinot-Peignoux, M et al, “Predictors of sustained response to alpha interferon therapy in chronic hepatitis C,” Journal of Hepatology 29:2 (pp. 214-223) Aug. 1998.
Lee, W.M., “Therapy of Hepatitis C: Interferon Alfa-2a trials.” Hepatology 26 (pp. 89S-95S) 1997.
Linsay, K.L., “Therapy of Hepatitis C: Overview” Hepatology 26 (pp. 71S-77S) 1997.
Marakami, T. et al, “Mutations in Nonstructural protein 5A gene and response to interferon in Hepatitis C virus genotype 2 infection.” Hepatology 30 (pp. 1045-1053) Oct. 1999.
Bukh Jens
Emerson Suzanne U.
Purcell Robert H.
Yanagi Masayuki
Housel James
Knobbe Martens Olson & Bear LLP
Li Bao Qun
The United States of America as represented by the Department of
LandOfFree
Cloned genome of infectious hepatitus C virus of genotype 2A... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloned genome of infectious hepatitus C virus of genotype 2A..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloned genome of infectious hepatitus C virus of genotype 2A... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3621610