Cloned genes which encode ELAM-1

Details Cloned genes which encode ELAM-1 Cloned genes which encode ELAM-1

1988-11-14

1992-01-14

Stone, Jacqueline

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4352402, 4353201, 4352523, 536 27, 935 9, 935 70, 935 71, 935 72, C07H 1510, C12N 510, C12N 113, C12N 1512

Patent

active

050810340

ABSTRACT:
The invention relates to cloned genes, or degenerate variants thereof, which encode endothelial-leukocyte adhesion molecule-1 (ELAM-1), or fragments thereof. Such fragments may be leukocyte or complement-binding. The invention also relates to cloned genes encoding fusion proteins comprising ELAM. The invention also relates to vectors containing the cloned genes of the invention, hosts transformed with the vectors, and the protein products expressed therefrom. The invention also relates to pharmaceutical compositions comprising the expressed proteins. The invention also relates to methods for the treatment of inflammation, post reperfusion injury, bacterial infections, vasculitis, leukemia, and methods of inhibiting metastatic spread of tumor cells by administering the pharmaceutical compositions of the invention.

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