Cloned genes for human dopamine D2 receptors and cell lines expr

Details Cloned genes for human dopamine D2 receptors and cell lines expr Cloned genes for human dopamine D2 receptors and cell lines expr

1989-09-27

1996-09-10

Fleisher, Mindy B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, 4351723, 4351722, 435 29, 436 63, 436501, 935 22, 935 76, C12Q 168, C12Q 100, C12N 1563, G01N 3348

Patent

active

055545009

ABSTRACT:
Disclosed herein is an isolated or essentially pure DNA sequence encoding a human Dopamine D2 receptor, the protein comprising the receptor, vectors for transforming or transfecting host cells with such DNA so that the cells express the DNA, methods of obtaining the DNA and preparing the transformed or transfected cells and cell lines, and methods of using the cells and cell lines in assays for the determination of human dopamine D2 receptor antagonists or agonists.

REFERENCES:
Bunzow et al. Nature 336(6201) 783-7 (1988) Chem Abstracts AN: CA 111(11):91464d.
Kobilka et al. Proc. Natl Acad Sci USA 84, pp. 46-50 Jan. 1987.
McGonigle et al. in Annals of the New York Academy of Sciences, vol. 430, 1984, pp. 77-90.
Stormann, et al., "Molecular Cloning and Expression of a Dopamine D2 Receptor from Human Retina", Molecular Pharmacology, 37:1-6.
Grandy, et al., "Cloning of the cDNA and Gene for a Human D2 Dopamine Receptor", Proc. Nat'l. Acad. Sci., vol. 86, Dec., 1989, pp. 9762-9766.
Toso, et al., "The Dopamine D2 Receptor: Two Molecular Forms Generated By Alternative Splicing", EMBO Journal, vol. 8, No. 13, pp. 4025-4034, 1989.
Botstein, et al., "Strategies and Applications of in Vitro Mutagenesis", Science, vol. 228, No. 4719, Sep., 1985, pp. 1193-1201.
Sokoloff, et al., "Molecular Cloning and Characterization of a Novel Dopamine Receptor (D3) as a Target For Neuroleptics", Nature, vol. 347, Sep., 1990, pp. 146-151.
Tol, et al., "Cloning of the Gene for a Human Dopamine D4 Receptor With High Affinity for the Antipsychotic Clozapine", Letters to Nature, vol. 350, Apr., 1991, pp. 610-614.
Tiberi, et al., "Cloning, Molecular Characterization, and Chromosomal Assignment of a Gene Encloding a Second D1 Dopamine Receptor Subtype: Differential Expression Pattern in Rat Brain Compared with the D1A Receptor", Proc. Natl., Acad. Sci. USA, vol. 88, Sep., 1991, pp. 7491-7495.
Sunahara, et al., "Cloning of the Gene for a Human Dopamine D5 Receptor with Higher Affinity for Dopamine than D1", Letters to Nature, vol. 350, Apr. 1991, pp. 614-619.

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