Cloned genes encoding recombinant protein A

Details Cloned genes encoding recombinant protein A Cloned genes encoding recombinant protein A

1982-10-27

1992-09-29

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 4352523, 43525233, 4353201, 536 27, 935 9, 935 11, 935 12, C12P 2102, C12N 1511, C12N 1531, C12N 1500

Patent

active

051513501

ABSTRACT:
The gene coding for a protein A-like material has been successfully cloned and expressed for the first time. The cloning of this gene with its nucleotide sequence characterization, also disclosed, enables those skilled in the art to obtain quantities of a protein A-like material nucleotide sequence for cloning in various host-vector systems. Protein A is well known as a valuable component of a variety of diagnostic test systems. The protein A-like material of the subject invention, and subfragments thereof, have the protein A properties of binding to IgG at the Fc region and activation of polyclonal antibody synthesis. Thus, these entities are useful in the same manner as protein A.

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