Cloned gene encoding rat D.sub.1B dopamine receptor

Details Cloned gene encoding rat D.sub.1B dopamine receptor Cloned gene encoding rat D.sub.1B dopamine receptor

1991-04-16

1993-06-01

Lacey, David L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 235, 536 2431, 536 243B, C12N 1512, C12N 1563

Patent

active

052159159

ABSTRACT:
Disclosed is isolated DNA encoding a D.sub.1B -dopamine receptor selected from the group consisting of: (a) isolated DNA which encodes rat D.sub.1B -dopamine receptor; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a D.sub.1B -dopamine receptor; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a D.sub.1B dopamine receptor Vectors and host cells containing the same, assay procedures employing D.sub.1B -dopamine receptors, oligonucleotide probes for identifying D.sub.1B -dopamine receptors, and isolated and purified D.sub.1B -dopamine receptors are also disclosed.

REFERENCES:
Science 237; 268-275, Jul. 17, 1987, Arriza et al. Cloning of Human Mineralocorticoid Receptor ComplementaryDNA: Structural and Functional Kinship with the Glucocorticoid Receptor.
Nature 329: 836-838, Oct. 29, 1987, Masu et al. cDNA cloning of bovine substance-K receptor through oocyte expression system.
Nature 347:72-76, Sep. 6, 1990, Dearry et al. Molecular Cloning and expression of the gene for a human D.sub.1, dopamine receptor.
Nature 347:76-80, Sep. 6, 1990, Zhou et al. Cloning and expression of human and rat D.sub.1 dopamaine receptors.
Nature 347:80-83, Sep. 6, 1990, Sunahara et al. Human dopamine D.sub.1 receptor encoded by an intronless gene on Chromosone 5.
PNAS87:2196-2200, Mar. 1990, Mahan et al. Expression of striatal D.sub.1 dopamine receptors coupled to inositol phosphate production and Ca.sup.2 + mobilization in xenopus oocytes.
F. Monsma et al., Proc. Natl. Acad. Sci. USA 87, 6723-6727 (1990). Sep.
P. Sokoloff et al., Nature 347, 146-151 (1990). Sep. 13.
G. Sheppard The Synaptic Organization of the Brain 2d Ed., 268-288, 308-337 (1979).
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