Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1994-01-13
2000-06-13
Guzo, David
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352402, 4353201, 530350, C12N 942, C12N 510, C12N 1563, C12N 1586
Patent
active
060748648
ABSTRACT:
Glucocerebrosidase produced by recombinant methods and having use for treatment of Gaucher's disease is disclosed. A cDNA for encoding the specific protein is taught along with the method of preparing the construct used to produce the protein.
REFERENCES:
patent: 4745051 (1988-05-01), Smith et al.
Retrovirus-mediated Transfer of the Human Glucocerebrosidase Gene to Gaucher Fibroblasts--Prabhakara V. et al.--Mol. Biol. Med. (1986) 3, 293-299.
Acid -Glucosidase: Enzymology and Molecular Biology of Gaucher Disease Gregory A. Grabowski et al.,--Biochemistry and Molecular Biology, vol. 25(6), 1990, pp. 385-414.
A mUtation In The Human Glucocerebrosidase Gene In Neuronopathic Gaucher's Disease--Tsuji et al.,--New England Journal of Med. 316:570-575 Mar. 5, 1987.
Genetic Heterogeneity In Type 1 Gacher Disease: Multiple genetypes in Ashkenazic and Non-Ashkenazic individuals Tsuji et al.,--Proc. Natl. Acad. Sci. USA, vol. 85, pp. 2349-2352, Apr. 1988 Medical Sciences.
Choudary, et al., "The Molecular Biology of Gaucher Disease and the Potential for Gene Therapy" Cold Spring Harbor Lab. 1986.
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Eliason William K.
Ginns Edward I.
LaMarca Mary E.
Martin Brian
Maysak Kara A.
Guzo David
The United States of America as represented by the Department of
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