Cloned DNA for P450scc and expression thereof

Details Cloned DNA for P450scc and expression thereof Cloned DNA for P450scc and expression thereof

1986-12-02

1991-09-03

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Vector, per se

435641, 435 701, 435 711, 435 91, 4351721, 4351723, 4352401, 4352523, 536 27, C12N 1552, C12N 1570, C12N 1574, C12N 1579

Patent

active

050454714

ABSTRACT:
A polynucleotide sequence encoding human P450scc is disclosed along with techniques for utilizing the P450scc expressed by this gene to reduce in vivo cholesterol levles.

REFERENCES:
patent: 4720454 (1988-01-01), White et al.
patent: 4757020 (1988-07-01), Beppu et al.
Matteson, K. J., et al., Study of Cholesterol Side-Chain Cleavage (20, 22 Demolase), Deficiency Cogentital Lipoid Adrenal Hyperplasia Using Bovine-Sequence P450scc Oligodeoxyribonucleotide Probes, Endocrinology (1986), 118 (4): 1296.
Morohashi, K., et al., Molecular Cloning and Nucleotide Sequence of cDNA for mRNA of Mitochrondrial Cytochrome P-450(scc) of Bovine Adrenal Cortex, Proc. Natl. Acad. Sci. USA (1984), 81: 4651.

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