Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-11-01
1995-05-23
Parr, Margaret
Chemistry: molecular biology and microbiology
Spore forming or isolating process
530350, 536 235, C12N 510
Patent
active
054181607
ABSTRACT:
The present invention relates to a fat cell specific rat .beta.-adrenergic receptor that mediates lipolysis in rats. The invention further relates to cloned cells which code for the specific .beta.-adrenergic receptor that mediates lipolysis. Another aspect of the present invention relates to a diagnostic test method for determining decreased levels of fat cell .beta.-adrenergic receptors that mediate lipotysis in order to diagnosis obesity caused by less active lipolysis.
REFERENCES:
patent: 5288607 (1994-02-01), Emorine et al.
Nahmias et al., EMBO J. 10(12), 3721-3727 (1991).
Muzzin et al., J. Biol. Chem. 266(35), 24053-24058 (1991).
Arch et al, Nature 309, 163-165.
Emorine et al., Scinece 245, 1118-1121.
Foster et al., "Nonshivering Thermogenesis in the Rat. II. Measurements of Blood Flow with Microspheres Point to Brown Adipose Tissue as the Dominant Site of the Calorigenesis Induced By Noradrenaline", Can. J. Physiol., vol. 56, 110 (1978).
Rothwell et al., "A Role for Brown Adipose Tissue in Diet-Induced Thermogenesis", Nature (London), vol. 281, 31 (1979).
C. A. Machida et al., "Molecular Cloning and Expression of the Rat .beta..sub.1 -Adrenergic Receptor Gene", J. Biol Chem 265, 12960 (1990).
D. A. Robinson, "Molecular Characterization of Cardiac .beta.-Adrenergic Receptors", Thesis, State University of New York at Buffalo (1988).
F. Z. Chung et al., "Cloning and Sequence Analysis of the Human Brain .beta.-Adrenergic Receptor", FEBS Lett. 211, 200 (1987).
R. A. F. Dixon et al., "Structural-Function Analysis of the .beta.-Adrenergic Receptor", Cold Spring Harbor Symp. Quant. Biol. 53, 487 (1988).
J. C. Venter et al., "Commentary: Molecular Biology of Adrenergic and Muscarinic Cholinergic Receptors", Biochem. Pharmacol. 38,1197 (1980).
C. M. Fraser, "Site-Directed Mutagenesis of .beta.-Adrenergic Receptors", J. Biol. Chem., 264, 9266 (1989).
C. F. Strader, et al. "Structural Basis of .beta.-Adrenergic Receptor Function", FASEB J. 3, 1825 (1989).
F. Z. Chung, et al. "Communication: Site-Directed Mutagenesis and Continuous Expression of Human .beta.-Adrenergic Receptors", J. Biol. Chem. 263, 4052 (1988).
H. Lehrach, et al. "RNA Molecular Weight Determinations by Gel Electrophorisis under Denaturing Conditons, A Critical Reexamination", Biochem. 16, 4743 (1977).
J. Gocayne et al., "Primary Structure of Rat Cardiac .beta.-Adrenergic and Muscarinic Cholinergic Receptor Obtained by Automated DNA Sequence Analysis: Further Evidence for a Multigene Family", Proc. Natl. Acad. Sci. USA 84, 8296 (1987).
J. Himms-Hagen, "Brown Adipose Tissue Thermogenesis and Obesity", Prog. Lip. Res. 28, 67 (1989).
F. Assimacopoulos-Jeannet, et al. "Alterations of Brown Adipose Tissue in Genetically Obese (ob/ob) Mice. II. Studies of .beta.-Adrenergic Receptors and Fatty Acid Degradaton", Endocrinol. 110, 439 (1982).
A. Marette, et al. "Defective Metabolic Effects of Norepinephrine and Insulin in Obese Zucker Rat Brown Adipose Tissue", Am. J. Physiol. 258, E320 (1990).
P. Muzzin, et al. "The Novel Thermogenic .beta.-Adrenergic Agonsit Ro 16-8714 Increases the Interscapular Brown-Fat .beta.-Receptor-Adenylate Cyclase and the Upcoupling-Protein mRNA Level in Obese (fa/fa) Zucker Rats", Biochem J. 261, 721 (1989).
Fraser Claire M.
Giacobino Jean-Paul
Venter J. Craig
Horlick Kenneth R.
Parr Margaret
The United States as represented by the Secretary of the Departm
LandOfFree
Cloned cell line expressing rat .beta..sub.3A adrenergic recepto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloned cell line expressing rat .beta..sub.3A adrenergic recepto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloned cell line expressing rat .beta..sub.3A adrenergic recepto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2140078