Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-06-17
1996-09-24
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 701, 4351723, 4352523, 43525233, 4353201, 435810, 536 237, 536 243, C07H 2102, C07H 2104, C12N 121, C12N 1570, C12P 2100, C12Q 168
Patent
active
055589936
ABSTRACT:
A polynucleotide encoding a 17-kD virulence protein, called EppA, from Borrelia burgdorferi is provided. The protein encoded by the polynucleotide of the invention is useful immunologically as a vaccine for Lyme borreliosis caused by B. burgdorferi. Methods and kits for detection of EppA polynucleotide are also provided.
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Marconi, et al., Analysis of the Distribution and Molecular Heterogeneity of the ospD Gene among the Lyme Disease Spirochetes: Evidence for Lateral Gene Exchange, Journal of Bacteriology, vol. 176, No. 15, pp. 4572-4582, Aug. 1994.
Lam, et al., Outer Surface Proteins E and F of Borrelia burgdorferi, the Agent of Lyme Disease, Infection and Immunity, vol. 67, pp. 290-298, Jan. 1994.
Aron, et al., Cloning and DNA sequence analysis of bmpC, a gene encoding a potential membrane lipoprotein of Borrelia burgdorferi, FEMS Microbiology Letters, vol. 123, pp. 75-82, 1994.
Blanco David R.
Champion Cheryl I.
Haake David A.
Lovett Michael A.
Miller James N.
The Regents of the University of California
Tran Paul B.
Zitomer Stephanie W.
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