Clodronate-containing medicaments and a process for the preparat

Details Clodronate-containing medicaments and a process for the preparat Clodronate-containing medicaments and a process for the preparat

1987-12-17

1989-08-22

Clingman, A. Lionel

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514960, A61K 914

Patent

active

048594725

ABSTRACT:
The present invention provides a medicament containing 80 to 95% clodronate, 2 to 10% filling material and 1 to 10% lubricant.
The present invention also provides a process for the production of a clodronate-containing medicament containing 80 to 95% clodronate, 2 to 10% filling material and 1 to 10% lubricant, wherein the dry components are mixed, moist granulated with an aqueous binding agent and the granulate obtained subsequently dried, a lubricant being additionally admixed with the final granulate in an amount of from 1 to 5% and the mixture thus obtained pressed into tablets or filled into capsules which have a rate of dissolving of >90% after 30 minutes.

REFERENCES:
patent: 4159346 (1979-06-01), Omura et al.
patent: 4614648 (1986-09-01), Bru
patent: 4687662 (1987-08-01), Schobel

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