Clock gene BMAL2

Details Clock gene BMAL2 Clock gene BMAL2

2006-07-11

2006-07-11

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Avian cell, per se

C536S023500

Reexamination Certificate

active

07074614

ABSTRACT:
The present invention provides novel clock proteins BMAL2 (Brain-Muscle-Arnt-Like protein2), which is crucial for the clock oscillation mechanism including photic-input pathway and output pathway, novel clock genes encoding the proteins, a screening method using the proteins to screen a promoter or a suppressor of the promoter transactivation, and the like.Genes for cCLOCK, cPER2, cBMAL1 were isolated from the chicken pineal gland which is a material suitable for studying circadian clock, then cDNA encoding the novel clock protein cBMAL2 having homology with cBMAL1 was isolated and sequenced. Further, BMAL2 cDNAs in human, mouse and rat were isolated respectively from the human embryonic kidney cell line, the mouse mid brain and the rat early fibroblast, and sequences of these cDNAs were determined. BMAL2 forms a heterodimer with CLOCK or BMAL1, etc. and it also forms a homodimer.

REFERENCES:
patent: WO 99/28464 (1999-06-01), None
patent: WO 00/09657 (2000-02-01), None
Abdrakhmanov et al., “A Large Database of Chicken Bursal ESTs as a Resource for the Analysis of Vertebrate Gene Function,” Genome Research, vol. 10, No. 12, pp. 2062-2069 (2000).
Gekakis, N. et al. “Role of the CLOCK protein in the mammalian circadian mechanism,” Science, 1998, vol. 280, pp. 1564-1569.
Hogenesch, J.B. et al. “Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.” J. Biol. Chem., 1997, vol. 272, p. 8581-8593.

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