Clock gene and methods of use thereof

Details Clock gene and methods of use thereof Clock gene and methods of use thereof

1998-06-19

2000-05-02

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 536 231, 536 232, 536 235, C12P 2102, C12N 1512, C12N 1563, C07H 2100

Patent

active

060571292

ABSTRACT:
The present invention provides isolated nucleic acids and/or recombinant DNA molecules that encode the clock protein DOUBLETIME. The present invention further provides both isolated and/or recombinant DOUBLETIME. In addition, the present invention provides antibodies to DOUBLETIME. Methods of using the nucleic acids, proteins and antibodies of the present invention, including as therapeutics are also provided.

REFERENCES:
patent: 5627064 (1997-05-01), Hoekstra
Harvey et al. (1997) Drosophila melanogaster cDNA clone HL01564, GenBank accession No. AA567638, GenBank record date Dec. 18, 1997, accessed Nov. 16, 1998.
Albrecht et al. Cell, 92:1055-1064 (1997).
Altschul et al., J. Mol. Biol. 215: 403-410 (1990).
Bargiello et al Proc. Natl. Acad. Sci. U.S.A. 81:2142-6 (1984).
Baylies et al. in Molecular Genetics of Biological Rhythms, pp. 123-153, M. W. Young, Ed. (Dekker, New York, 1993).
Cavener, NAR, 15: 1353-1361 (1987).
Crews et al Cell 52:143-51 (1988).
Crosthwaite et al., Science, 276:763-769 (1997).
Curtin et al., Neuron, 14:365-372 (1995).
Dembinska et al., J. Biol. Rhythms, 12:157-172 (1997).
Dunlap et al., Annu. Rev. Genet., 30:579-601 (1996).
Edery et al Proc. Natl. Acad. Sci. U.S.A. 91:2260-4 (1994).
Ewer et al., J. Neurosci., 12:3321-3349 (1992).
Fish et al., Journ. Biol. Chem, 270:14875-14883 (1995).
Frisch et al., Neuron, 12:555-570 (1994).
Gekekis et al., Science, 270:811-815 (1995).
Giebultowicz and Hege, Nature, 386:664 (1997).
Hamilton et al., NAR 19:1951-1952 (1991).
Hanks et al., Science 241: 42-54 (1988).
Hardin et al, Proc. Natl. Acad. Sci. U.S.A. 89:11711 (1992).
Hardin et al, Nature 343:536-40 (1990).
Helfrich-Forster, Proc. Natl. Acad. Sci. USA, 92:612-616 (1995).
Huang et al Nature 364:259-72 (1993).
Hunter-Ensor et al., Cell, 84:677-685 (1996).
Jackson, in Molecular Genetics of Biological Rhythms, pp. 91-121, M. W. Young, Ed. (Dekker, New York, 1993).
James et al EMBO J. 5:2313 (1986).
Kaneko et al., Neurosci., 17:6745-6760 (1997).
Kelley et al., Mol. and Cell Bio., 7:1545-1548 (1987).
King et al., Cell, 89:641-653 (1997).
Kondo et al., Science, 266:1233-1236 (1994).
Konopka and Benzer Proc. Natl. Acad. Sci. U.S.A. 68:2112 (1971).
Kunes et al. J. Neurosci., 13:752-767 (1993).
Lee et al., Science, 271:1740-1744 (1996).
Leloup and Goldbeter, J. Biol. Rhythms, 13:70-87 (1998).
Millar et al., Science, 267:1161-1163 (1995).
Myers et al., Science, 271:1736-1740 (1996).
Myers et al., Nucl. Acids Res., 25:4710-1714 (1997).
Nambu et al Cell 67:1157-67 (1991).
Pittendrigh, in Handbook of Behavioral Neurobiology, 4, J. Aschoff, Ed., New York: Plenum, 1981, pp. 95-124.
Price et al., EMBO J., 14:4044-4049 (1995).
Ralph and Menaker, Science, 241:1225-1127 (1988).
Rosbash et al., Harb. Symp. Quant. Biol. J., 61:265-278 (1996).
Rutila et al., Neuron, 17:921-929 (1996).
Saez and Young, Neuron, 17:911-920 (1996).
Sehgal et al., Proc. Natl. acad. Sci USA, 89:1423-1427 (1992).
Sehgal et al. Science 263:1603 (1994).
Sehgal et al., Science, 270:808-810 (1995).
Siwicki et al Neuron 1:141-50 (1988).
Stanewsky et al., J. Neurosci., 17:676-696 (1997).
Sun et al., Cell 90:1003-1011 (1997).
Tautz and Pfeifle Chromosoma 98:81-85 (1989).
Tei et al., Nature, 389 (1997).
Vitaterna et al., Science, 264:719-725 (1994).
Vosshall et al., Science, 263:1606-1609 (1994).
Vosshall and Young, Neuron, 15:345-360 (1995).
Zeng et al., Nature, 380:129-135 (1996).

Affiliated with

Also associated with

Rating

Clock gene and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Clock gene and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Clock gene and methods of use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1592816