Clinical use of somatostatin analogues

Details Clinical use of somatostatin analogues Clinical use of somatostatin analogues

1983-11-14

1986-09-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514806, 530311, A61K 3724, C07K 726

Patent

active

046123024

ABSTRACT:
A method of increasing the clearance of particles from the blood stream of a vertebrate, which comprises administering to a vertebrate having a surplus of particles in the blood stream of the vertebrate an amount of a somatostatin analogue sufficient to increase phagocytosis in the vertebrate is disclosed along with a method treating vascular lesions or deterioration of biological membranes comprising the step of administering to a human or other mammal suspected of having one or more vascular lesions or of having deterioration of a biological membrane in the liver of said human or mammal an amount of a somatostatin analogue sufficient to reduce the number or severity of said lesions or to prevent further deterioration or reduce the extent of deterioration of said membrane.

REFERENCES:
patent: 4224199 (1980-09-01), Meyers et al.
patent: 4280953 (1981-07-01), Guillemin et al.
patent: 4310518 (1982-01-01), Freidinger et al.
patent: 4316890 (1982-02-01), Kamber et al.
patent: 4316891 (1982-02-01), Guillemin et al.
patent: 4328214 (1982-04-01), Rink et al.
patent: 4360516 (1982-11-01), Freidinger et al.
patent: 4366148 (1982-12-01), Szabo et al.
patent: 4369179 (1983-01-01), Rink et al.
Veber et al., Nature, 292, 55-58, (1981).

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