Cleaving double-stranded DNA with peptide nucleic acids

Details Cleaving double-stranded DNA with peptide nucleic acids Cleaving double-stranded DNA with peptide nucleic acids

1993-07-02

1997-06-24

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536243, C12Q 168

Patent

active

056416253

ABSTRACT:
Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.

REFERENCES:
patent: 5134066 (1992-07-01), Rogers et al.
Demidov et al., Nuc. Acids Res., 21(19):2103-2107, May 11, 1993.
Egholm, J. Chem. Soc., Chem. Commun., pp. 800-801, May 1993.
McCurdy et al., "Deoxyoligonucleotides with Inverted Polarity: Synthesis and Use in Triple-Helix Formation," Nucleosides and Nucleotides, 10:287-290, 1991.
Nielsen et al., "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide," Science, 254:1497-1500, 1991.
Foehler et al., "Oligodeoxynucleotides Containing C-5 Propyne Analogs of 2'-Deoxyuridine and 2'-Deoxycytidine," Tetrahedron Letters, 33:5307-5310, 1992.
Sagi et al., "Base-Modified Oligodeoxynucleotides. I. Effect of 5-Alkyl, 5-(1-Alkenyl) and 5-(1-Alkynyl) Substitution of teh Pyrimidines on Duplex Stability and Hydrophobicity," Tetrahedron Letters, 34:2191-2194, 1993.
Egholm et al., "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with and Achiral Peptide backbone," J. Am. Chem. Soc., 114:1895-1897, 1992.
Spalholtz et al., "Bovive papillomavirus Transcriptional Regulation: Localization of the E2-Responsive Elements of the Long Control Region," J. Virol., 61:2128-2137, 1987.
Dubochet et al., "A New Preparation Method for Dark-Field Electron Microscopy of Biomacromolecules," J. Ultrastruct. Res., 35:147-167, 1971.
Vickers et al., "Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element," Nucleic Acids Research, 19:3359-3368, 1991.
Stenberg et al., "Promoter-Specific trans Activation and Repression by Human Cytomegalovirus Immediate-Early Proteins Invovles Common and Unique Protein Domains," J. Virol., 64:1556-1565, 1990.
Hahn et al., "Molecular cloning and characterization of the HTLV-III virus associated with AIDS," Nature, 312:166-169, 1984.
Depto et al., "Regulated Expression of the Human Cytomegalovirus pp65 Gene: Octamer Sequence in the Promoter Is Required for Activation by Viral Gene Products," J. Virol., 1989, 63:1232-1238, 1989.
Tibanyenda et al., "The effect of single base-pair mismatches on the duplex stability of d(T-A-T-T-A-A-T-A-T-C-A-A-G-T-T-G) . d(C-A-A-C-T-T-G-A-T-A-T-T-A-A-T-A)," Eur. J. Biochem., 139:19-27, 1984.
Vasseur et al., "Oligonucleosides: Synthesis of a Novel Methylhydroxylamine-Linked Nucleoside Dimer and Its Incorporation into Antisense Sequences," J. Am. Chem. Soc., 114:4006-4007, 1992.
Lal et al., "Diphenylphosphoryl Azide A Novel Reagant for the Stereospecific Synthesis of Azides from Alcohols," Tetrahedron Letters, 23:1977-1980, 1977.
Doel et al., Tetrahedron, 30:2755-2759 1974.

Affiliated with

Also associated with

Rating

Cleaving double-stranded DNA with peptide nucleic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cleaving double-stranded DNA with peptide nucleic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cleaving double-stranded DNA with peptide nucleic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-148385