Cleavage site blocking antibody to prohormone proteins and uses

Details Cleavage site blocking antibody to prohormone proteins and uses Cleavage site blocking antibody to prohormone proteins and uses

1995-04-18

1997-10-14

Loring, Susan A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

435336, 435331, 435346, 5303871, 5303873, 5303881, 53038823, 53038824, 5303891, 5303892, 530809, C12N 512, C12N 522, C07K 1600, C07K 1624

Patent

active

056771827

ABSTRACT:
Cleavage site blocking antibody that binds to prohormones, preferable Tumor Necrosis Factor, thereby preventing the formation of prohormone fragment(s) by proteolysis of the prohormone, and uses of the antibody including prophylactic and therapeutic methods to treat disease, and diagnostic assays for determining the amount of the prohormone and prohormone fragments present in a patients body.

REFERENCES:
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Kriegler, M. et al., Cell, 53:45-53, Apr. 8, 1988.
Kohler et al., Nature, 256:495-499, Aug. 7, 1975.
Milstein, C. et al., Immun. Today, 5(10): 299-304, 1984.
Fendly, B. M., Hybridoma, 6(4): 359-370, 1987.
Waldmann, T. A., Science, 252: 1657-1662, Jun. 11, 1991.
Craig, C., BioWorld Today, 5(138): 1 and 3, Jul. 19, 1994.
Rhein, R., Biotechnology Newswatch, Oct. 4, 1993, pp. 1 and 3.
Pemmington, J., ASN News, 58(9), Sep. 1992.

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