Cleavage of nucleic acids

Details Cleavage of nucleic acids Cleavage of nucleic acids

2007-02-16

2010-10-05

Whisenant, Ethan (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100, C536S024300

Reexamination Certificate

active

07807365

ABSTRACT:
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of cleaving the cleavage structure with a nuclease to release a nucleic acid fragment to generate a signal, wherein generation of the signal is indicative of the presence of a target nucleic acid in a sample.

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Davis et al. Basic Methods in Molecular Biology pp. 268-273 (1986) published by Elsevier Science Publishing ,NY, NY.

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