Cleavable thiocarbonate linkers for polynucleotide synthesis

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S025300

Reexamination Certificate

active

07855281

ABSTRACT:
In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.

REFERENCES:
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patent: 6673918 (2004-01-01), Bellon et al.
patent: 2005/0048497 (2005-03-01), Dellinger et al.
patent: 2005/0136477 (2005-06-01), Akhavan-Tafti
patent: 2007/0100136 (2007-05-01), Dellinger et al.
McIsaac et al., The Nucleophilic Reactivity of Peroxy Anions, J. Org. Chem., vol. 37, No. 7, 1972 pp. 1037-1041.

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