Cleavable diphosphate and amidated diphosphate linkers

Details Cleavable diphosphate and amidated diphosphate linkers Cleavable diphosphate and amidated diphosphate linkers

1989-06-30

1992-03-10

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

530345, 530405, 530409, 530332, 5303915, 5303919, 514 2, 514 21, 536 51, 424 9, 424 11, A61K 3944, C07K 1710, C07K 1706

Patent

active

050948482

ABSTRACT:
The specificity of a pharmaceutical agent for a given site of action is increased by covalently bonding the agent via a diphosphate or amidated diphosphate bond to a targeting moiety, preferably a polypeptide specific for the site.

REFERENCES:
Gregoriadis (1980) Pharmac. Ther. 10:103-118.
Ghose et al. (1982) Nato. Adv. Study Inst. Ser., Ser A, vol. 47, pp. 55-82.
Blair et al. (1983) J. Immunol. Methods, 59:129-143.
Molteni (1979) in Drug Carriers in Biology and Medicine pp. 107-128 Academic Press.
Hong et al., Biochem. Biophys. Res. Comm., 94, (1980) 1169.
Ryu et al., Med. Chem., 25, (1982) 1322.
Hong et al., J. Med. Chem., 28, (1985) 171.
Rosowsky et al., J. Med. Chem., 25, (1982) 171.
Hong et al., J. Med. Chem., 31, (1988) 1793.

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