Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-05
1997-04-29
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, 530386, 530362, 530363, 530402, 530410, 5483037, A61K 3838, C07D23502
Patent
active
056248962
ABSTRACT:
Novel clearing agents are provided which comprise biotin analog containing clearance-directing moieties. Preferably such clearance-directing moieties endogenously contain or a rederivatized to expose galactose and/or mannose residues.
REFERENCES:
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4904481 (1990-02-01), Fathman et al.
patent: 5215927 (1993-06-01), Berenson et al.
patent: 5256395 (1993-10-01), Barbet et al.
patent: 5332679 (1994-07-01), Simons et al.
Sheldon et al., Appl. Radiat. Isot., vol. 43, No. 11, pp. 1399-1402, 1992, "Targeting of [111-In] Biocytin to Cultured Ovarian Adenocarcinoma Cells Using Covalent Monoclonal Antibody-Streptavidin Conjugates".
Sharon and Lis, Scientific American, vol. 268, No. 1, pp. 82-89, 1993, "Carbohydrates in Cell Recognition".
Goodwin, J. Nucl. Med., vol. 33, No. 10, pp. 1816-1818, 1992, "New Methods for Localizing Infection: A role for Avidin-Biotin?".
Goodwin et al., J. Nucl. Med., vol. 33, No. 11, pp. 2006-2013, 1992, "Pretargeted Immunoscintigraphy: Effect of Hapten Valency on Murine Tumor Uptake".
Kock and Macke, Angew. Chem. Intl. Ed. Engl., vol. 31, No. 11, pp. 1507-1509, 1992, "99m-Tc Labeled Biotin Conjugate in a Tumor" Pretargeting Approach with Monoclonal antibodies.
Goodwin et al., J. Nucl. Med., p. 880, 1992, Abstract No. 232, "Pharmacokinetics of Biotin-Chelate Conjugates for Pretargeted Avidin-Biotin Immunoscintigraphy".
Morell et al., J. Biol. Chem., vol. 246, No. 1, pp. 1461-1467, 1971, "The Role of Sialic Acid in Determining the Survival of Glycoproteins in the Circulation".
Tolleshaug, Int. J. Biochem., vol. 13, pp. 45-51, 1981, "Binding and Internalization of Asialoglycoproteins by Isolated Rat Hepatocytes".
Wall et al., Cell, vol. 21, pp. 79-93, 1980, "The Galactose-Specific Recognition System of Mammalian Liver: the Route of Ligand Internalization in Rat Hepatocytes".
Galli et al., J. Nucl. med., vol. 32, No. 2, pp. 110-116, 1988, "A Radiopharmaceutical for the Study of the Liver: 99m-Tc-DTPA-Asialo-Orosomucoid I: Radiochemical and Animal Distribution Studies".
Sharma et al., Br. J. Cancer, vol. 61, pp. 659-662, 1990, "Inactivation and Clearance of an anti-CEA carboxypeptidase G2 Conjugate in Blood after Localization in a Xenograft Model".
Jansen et al., J. of Biological Chem., vol. 226, No. 5, pp. 3343-3348, 1991, "Hepatic Endocytosis of Various Taypes of Mannose-terminated Albumins".
Lee et al., Biochemistry, vol. 15, No. 18, pp. 3956-3962, 1976, "2-Imino-2-methoxyethyl 1-thioglycosides: New Reagents for Attaching Sugars to Proteins".
Krantz et al., Biochemistry, vol. 15, No. 18, pp. 3963-3968, 1976, "Attachment of Thioglycosides to Proteins: Enhancement of Liver Membrane Binding".
International Search Report for PCT Patent Application No.: PCT/US93/05406.
Green, Biochem. J., 89:585, 1963, "The Use of [.sup.14 C] Biotin for Kinetic Studies and for Assay".
Kalofonos et al., J. Nucl. Med., vol. 31, No. 11, pp. 1791-1796, 1990, "Imaging of Tumor in Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communication".
Hnatowich et al., J. Nucl. Med., vol. 28, No. 8, pp. 1294-1302, 1987, "Investigations of Avidin and Biotin for Imaging Applications".
Paganelli et al., Int. J. Cancer, 45:1184-1189, 1990, "Intraperitoneal Radio-Localization of Tumors Pre-Targeted by Biotinylated Monoclonal Antibodies".
Paganelli et al., Nuclear Medicine Communications, 12:211-234, 1991, "Monoclonal antibody pretargeting techniques for tumour localization: the avidin-biotin system".
Goodwin/Hnatowich, J. Nucl. Med., vol. 32, No. 4, pp. 750-751, 1991, Letter to the Editor/Replay.
Rosebrough, J. Nucl. Med., p. 880, 1992, Abstract No. 235, "Plasma Stability and Pharmacokinetics of Radio-Labeled Deferoxamine-Biotin Derivatives".
Virzi et al., J. Nucl. Med., p. 920, 1992, Abstract No. 403, "The Preparation and Evaluation of 12 Biotin Derivatives Labeled with Tc-99M".
Rosario et al., J. Nucl. Med., vol. 32, No. 5, p. 993, 1991, Abstract No. 356, "Bolton-Hunter and Biotin Derivatized Polylysine: A New Multi-Valent Peptide Reagent for In Vivo Pre-Targeting with Streptavidin Conjugates".
R. T.Lee et al, Glycoconjugate, "Preparation of Cluster Glycosides of N-Acetylgalactosamine That Have Subnanomolar Binding Constants Towards the Mammalian Hepatic Gal/GalNAc-specific Receptor", vol. 4, (1987), pp. 317-328.
R. T. Lee et al, Biochemistry, "New Synthetic Cluster Ligands for Galactose/N-Acetylgalactosamine-Specific Lectin of Mammalian Liver", vol. 23, (1984), pp. 4255-4261.
J. R. Merwin et al, Bioconjugate Chem., "Targeted Delivery of DNA Using YEE(GalNAcAH).sub.3, a Synthetic Glycopeptide Ligand for the Asialoglycoprotein Receptor", vol. 5 (1994), pp. 612-620.
M. A. Findeis, Int. J. Peptide Protein Res., "Stepwise synthesis of a GalNAc-containing cluster glycoside ligand of the asialoglycoprotein receptor", vol. 43, (1994), pp. 477-485.
T. D. McKee et al., Bioconjugate Chem., "Preparation of Asialoorosomucoid-Polylysine Conjugates", vol. 5, (1994), pp. 306-311.
E. A. L. Biessen et al, J. Med. Chem., "Synthesis of Cluster Galactosides with High Affinity for the Hepatic Asialoglycoprotein Receptor", vol. 38, No. 9, (1995), pp. 1538-1546.
Mattes et al., JNCL, 1987, 79(4):855.
Axworthy Donald B.
Reno John M.
Eisenschenk Frank C.
NeoRx Corporation
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