Clear, water-miscible, liquid pharmaceutical vehicles and compos

Details Clear, water-miscible, liquid pharmaceutical vehicles and compos Clear, water-miscible, liquid pharmaceutical vehicles and compos

1977-11-18

1980-02-12

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424177, 424181, 424228, 424243, 424250, 424273R, 424324, 424330, A61K 3174

Patent

active

041883730

ABSTRACT:
Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiologically-acceptable, liquid compositions which gel to a thickened, non-flowing and adhering consistency at human body temperature. They are liquid at ambient room temperature and have a gel transition temperature in the range of from about 25.degree. C. to about 40.degree. C. Aqueous solutions of certain polyoxyethylene-polyoxypropylene condensates are suitable vehicles. Also provided are pharmaceutical compositions containing added pharmacologically active chemical material, i.e., a drug or medicament. A method of delivering the drug or medicament to a mucous membrane is also provided.

REFERENCES:
patent: 3422186 (1969-01-01), Sasmor
patent: 3740421 (1973-06-01), Schmolka
patent: 3767788 (1973-10-01), Rankin
patent: 3867533 (1975-02-01), Schmolka
patent: 3882036 (1975-05-01), Krezanoski et al.
patent: 3884826 (1975-05-01), Phares et al.

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