Clear non-alcoholic hydrocortisone solutions

Details Clear non-alcoholic hydrocortisone solutions Clear non-alcoholic hydrocortisone solutions

1996-03-18

1998-03-17

Criares, Theordore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

424 7805, 514975, 514424, 514400, 514952, 514970, 514973, A61K 3156, A61K 3174

Patent

active

057286906

ABSTRACT:
This invention relates to clear aqueous solutions of hydrocortisone which are free of lower alcohols. When applied to the skin, either directly or by wipe, the solution is practically invisible and has a further advantage that the solution will not irritate or dry the skin or give the stinging sensation of an alcohol containing solution. Dissolution of hydrocortisone without alcohol is accomplished by using the anionic surfactant sodium dioctyl sulfosuccinate in mixtures of glycerin, propylene glycol and polyethylene glycol diluted to final volume with water.

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V. Das Gupta, Drug Development and Industrial Pharmacy 11(12), 2083097 (1985).
Hajratwala, J. Pharm. Pharmacology 28, 934 (1976).
Barry, J. Pharm. Pharmacology 28, 210 (1976).

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