Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-05-01
1986-02-25
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
4241951, 514167, 514168, 514546, 514552, 514558, 514725, 514904, A61K 3159, A61K 3120, A61K 31045, A61K 31355
Patent
active
045729158
ABSTRACT:
Micellized aqueous formulations for fat soluble vitamins, essential nutrients, herb oils and pharmaceutical agents are obtained by a process wherein the fat soluble vitamin, essential nutrient or agent is first admixed with a suitable amount of polyethoxylated castor oil and a pharmaceutically acceptable polyol, such as glycerol to provide a non-aqueous phase. Thereafter, an aqueous phase containing mostly water and optionally a preservative, such as sodium benzoate, is slowly added to the agitated non-aqueous phase in such a manner that the temperature of the non-aqueous phase, including the aqueous phase added thereto, is maintained at an elevated temperature, preferably between approximately 60.degree. to 100.degree. C. After cooling, the final admixture is clear, homogeneous, having micelles of approximately 2 microns or smaller size. Human subjects exhibit significantly higher blood plasma levels of vitamins A and E after ingestion of the formulation of the present invention, then after ingestion of comparable doses of prior art vitamin A and E formulations.
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McCutcheon's-Detergent & Emulsifiers-1971 Annual-Emulphor EL.
Chem. Abst., 84:126779(p) (1976)-Joachim.
Chem. Abst., 85:72466(j) (1976)-Kettler et al.
Chem. Abst., 85:166640(p) (1976)-Josse.
Chem. Abst., 100:39628(n) (1984)-Richter et al.
Bioglan Laboratories
Bioglan, Inc.
Robinson Douglas W.
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