Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Reexamination Certificate
2005-05-10
2005-05-10
Spivak, Phyllis G. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
C514S458000
Reexamination Certificate
active
06890961
ABSTRACT:
A clear aqueous formulation for topical application in the oral cavity of humans to treat leukoplakia contains water, β-carotene, a water miscible polyol, an unsaturated fatty acid ester, and a surfactant, preferably polyethoxylated castor oil or POE(20) sorbitan monooleate. The formulation preferably also contains a pharmaceutically acceptable anti-oxidant, preferably d-alpha-tocopherol (vitamin E), and is in the form of an oral rinse or as a gel well suited for spreading on gums or other parts of the oral cavity. The formulation is applied in a gel form on a substantially regular daily basis to areas in the oral cavity where leukoplakia lesions are present. Persistent application of the gel results in substantial diminution or total elimination of the leukoplakia lesions.
REFERENCES:
patent: 4572915 (1986-02-01), Crooks
patent: 6495532 (2002-12-01), Bathurst et al.
patent: WO 9421231 (1994-09-01), None
patent: WO 9527483 (1995-10-01), None
Database Biosis 'Online! Biosciences Information Service, Philadelphia, AP, US; (Dec. 1999) & Archives of Otolaryngology Head & Neck Surgery, vol. 125, No. 12, (Dec. 1999), p. 1305-1310, ISSN: 0886-4470.
Alosio Edward
Dema-Ala Brincini Faith
Li Wenjie
Rutolo, Jr. David a.
Micelle Products, Inc.
Spivak Phyllis G.
Szekeres Gabor L.
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