Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1993-11-03
1996-10-15
Nutter, Nathan M.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
523113, C08G 6348, C08G 6391
Patent
active
055655190
ABSTRACT:
Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantially nonfibrillar form at pH 7 and is preferably succinylated or methylated collagen. The synthetic hydrophilic polymer is preferably an activated polymeric glycol, most preferably, a di- or multifunctionally activated polyethylene glycol. Materials and devices formed with the chemically modified collagen-synthetic polymer conjugates have good optical clarity, mechanical strength, and moldability.
REFERENCES:
patent: 3619371 (1971-11-01), Crook et al.
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3876501 (1975-04-01), Hanushewsky
patent: 3949073 (1976-04-01), Daniels et al.
patent: 3960830 (1976-06-01), Bayer et al.
patent: 4002531 (1977-01-01), Royer
patent: 4055635 (1977-10-01), Green et al.
patent: 4088538 (1978-05-01), Schneider
patent: 4164559 (1979-08-01), Miyata et al.
patent: 4179337 (1979-12-01), Davis
patent: 4192021 (1980-03-01), Deibig et al.
patent: 4261973 (1981-04-01), Lee et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4314380 (1982-02-01), Miyata et al.
patent: 4357274 (1982-11-01), Werner
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4414147 (1983-11-01), Klibanov et al.
patent: 4415665 (1983-11-01), Mosbach et al.
patent: 4424208 (1984-01-01), Wallace et al.
patent: 4451568 (1984-05-01), Schneider et al.
patent: 4488911 (1984-12-01), Luck et al.
patent: 4495285 (1985-01-01), Shimizu et al.
patent: 4496698 (1985-01-01), Mitra
patent: 4557764 (1985-12-01), Chu
patent: 4563490 (1986-01-01), Stol et al.
patent: 4582640 (1986-04-01), Smestad et al.
patent: 4592864 (1986-06-01), Miyata et al.
patent: 4642117 (1987-02-01), Nguyen et al.
patent: 4678468 (1987-07-01), Hiroyoshi
patent: 4687820 (1987-08-01), Hou et al.
patent: 4689399 (1987-08-01), Chu
patent: 4703108 (1987-10-01), Silver et al.
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4737544 (1988-04-01), McCain et al.
patent: 4745180 (1988-05-01), Moreland et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4828563 (1989-05-01), Muller-Lierhern
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4923467 (1990-05-01), Thompson
patent: 4935465 (1990-06-01), Garman
patent: 4979959 (1990-12-01), Guire
patent: 5156622 (1992-10-01), Thompson
patent: 5162430 (1992-11-01), Rhee et al.
patent: 5163956 (1992-11-01), Liu et al.
patent: 5196027 (1993-03-01), Thompson et al.
patent: 5201764 (1993-04-01), Kelman et al.
Document Number 07/907,518 Rhee et al. Jul. 2, 1992.
Abuchowski et al., "Cancer Therapy with Chemically Modified Enzymes. I. Antitumor Properties of Polyethylene Glycol-Asparaginase Conjugates," Cancer Biochem Biophys (1984) 7:175-86.
Bendich, A. et al., "Immunological Effects of Native and Polyethylene Glycol-Modified Asparaginases from Vibrio Succinogenes and Escherichia Coli in Normal and Tumour-Bearing Mice," Clin Exp Immunol (1982) 48:273-78.
Chen, R. H. L. et al., "Properties of Two Urate Oxidases Modified by the Covalent Attachment of Poly(ethylene Glycol)," Biochim Biophys Acta (1981) 660:293-98.
Chvapil, M. et al., "Some Chemical and Biological Characteristics of a New Collagen-Polymer Compound Material," J Biomed Mater Res (1969) 3:315-32.
Davis et al., "Hypouricaemic Effect of Polyethyleneglycol Modified Urate Oxidase," Lancet (1981) 2:281-83.
Inada et al., "Ester Synthesis Catalyzed by Polyethylene Glycol-Modified Lipase in Benzene," Biochem & Biophys Res Comm (1984) 122:845-50.
Llyod et al., "Coupling of Acrylic Polymer and Collagen by Use of a Water-Soluble Carbodiimide," J Polymer Sci. Chem Ed. (1979) 17:3473-3483.
Nishida et al., "Hypouricaemic Effect after Oral Administration in Chickens of Polyethylene Glycol-Modified Uricase Entrapped in Liposomes," J Pharm Pharmacol (1984) 36:354-55.
Pyatak, P. S. et al., "Preparation of a Polyethylene Glycol: Superoxide Dismutase Adduct, and an Examination of it Blood Circulating Life and Anti-Inflammatory Activity," Res Com Chem Path Pharmacol (1980) 29:113-27.
Ramshaw, J. A. M. et al., "Precipitation of Collagens by Polyethylene Glycols," Anal Biochem (1984) 141:361-65.
Savoca, K. V. et al., "Preparation of a Non-immunogenic Arginase by the Covalent Attachment of Polyethylene Glycol," Biochem Biophys Acta (1979) 578:47-53.
Takahashi et al., "A Chemical Modification to Make Horseradish Peroxidase Soluble and Active in Benzene," Biochem & Biophys Res Comm (1984) 121:261-65.
Viau, A. T. et al. "Safety Evaluation of Free Radical Scavengers PEG-Catalase and PEG-Superoxide Dismutase," J Free Rad in Bio & Med (1986) 2:283-288.
Viau, A. T. et al. "Toxicologic Studies of a Conjugate of Asparaginase and Polyethylene Glycol in Mice, Rats, and Dogs," Am J Vet Res(1986) 47:1398-401.
Wieder, K. J. et al., "Some Properties of Polyethylene Glycol: Phenylalanine Ammonia-Lyase Adducts," J Biol Chem (1979) 254:12579-87.
Chu George H.
DeLustro Frank A.
Rao Prema R.
Rhee Woonza M.
Church Shirley L.
Collagen Corporation
Nutter Nathan M.
Rafayko Kathi
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