Clear aqueous composition comprising propofol and...

Details Clear aqueous composition comprising propofol and... Clear aqueous composition comprising propofol and...

2006-11-21

2006-11-21

Maier, Leigh C. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S731000

Reexamination Certificate

active

07138387

ABSTRACT:
Sterile pharmaceutical stable autoclaved clear aqueous compositions of propofol (2,6-Diisopropyl phenol) suitable for parenteral administration are described. The compositions essentially consist of a complex of propofol with 2-hydroxypropyl-β-cyclodextrin in a weight ratio of 1:30–1:60. This complex of propofol with 2-hydroxypropyl-β-cyclodextrin produces a clear aqueous composition that is stable to autoclaving. The composition is effective as an anaesthetic agent. The process of making these synergistic compositions has been described.

REFERENCES:
patent: WO 96/32135 (1996-10-01), None
Trapani, G. et al “Inclusion Complexation of Propofol . . . ” J. Pharm. Sci. (1998) vol. 87, No. 4, pp. 514-518.
MacKenzie, C. “Formulation and evaluation of a propanidid . . . ” Int. J. Pharm. (1997) vol. 159, pp. 191-196.

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