Cleaning contact lenses with solution of bromelain and carboxype

Details Cleaning contact lenses with solution of bromelain and carboxype Cleaning contact lenses with solution of bromelain and carboxype

1982-02-05

1985-06-04

Marantz, Sidney

Cleaning and liquid contact with solids

Processes

Using sequentially applied treating agents

134 42, 25217412, 252DIG12, B08B 308, C12N 948, C12N 950

Patent

active

045212546

ABSTRACT:
A method and composition for the effective cleaning and treatment of soft, high water content, contact lenses, particularly the non-aphakic lens approved for general extended use and the aphakic lenses approved for prescribed use as a method of visual correction for the aphake. The method comprises immersing the lens in an aqueous solution which includes the protease, bromelain, as a principal ingredient and a further minor portion of carboxypeptidase enzyme, as the cleansing and treatment agent. The combination of bromelain and carboxypeptidase enzymatic agents produces surprisingly better cleansing results, in substantially shorter time, than either agent alone. The solution removes protein, mucin, lipid, calcium, mineral, and other physiologically encountered debris from the lens; and the lens so treated shows enhanced resistance to the accumulation of further deposits when subsequently worn by the patient.

REFERENCES:
patent: 3634191 (1972-01-01), Laboureur
patent: 3720402 (1973-03-01), Cummins et al.
patent: 3910296 (1975-10-01), Karageozian et al.
patent: 4096870 (1978-06-01), Manfuso
patent: 4285738 (1981-08-01), Ogata
patent: 4323467 (1982-04-01), Fu
Mihalyi, E., Application of Proteolytic Enzymes to Protein Structure Studies`, (1978), pp. 43-93.
Coorman, W. M. et al., "Bromelain, Biochemical and Pharmacological Properties," Pharm. Acta. Helv., 51, Nr. 4, (1976), 73, 112.
Spinell, M., A Clinical Guide to Soft Contact Lenses, (1979), pp. 3, 4, 13-15, 185, 186, 193-195.
Physician's Desk Reference, (1981), p. 1548.
Doi, E. et al., "Carboxypeptidase in Commercial Bromelain Power," J. Biol. Chem., 1063, (1973).

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