Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof
Patent
1980-02-15
1982-12-14
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Ammonia, amine, or derivative thereof
424 49, A61K 722
Patent
active
043637957
DESCRIPTION:
BRIEF SUMMARY
When teeth are mended, especially teeth attacked by caries, the tooth is usually bored (ground) and the attacked dentine is removed. An amorphous smear layer will then be produced adhering to the dentinal surface due to electrostatic attraction. The smear layer adhering to the dentine surface may contain microorganisms which can survive and grow below most types of fillings and their metabolism products may also damage the pulp. Thus, this amorphous smear layer should be removed and the dentinal surface be treated with an antibacterial cleaning solution as final step before filling or coating with a liner. It is essential that this is done so that the risk of bacterial growth in the space close to the dentinal surface is reduced as the retention of cement in the material insulating the dentine is improved. Such solutions should not have an irritating effect on the pulp when applied for about one minute. The known removal of the smear layer with demineralizing solutions is a questioned practice. While application of an acid on a dentinal surface for one minute has no irritating effect on the pulp, the orifices of the dentine channels expand and open and an even, organic film will remain between the channels. Therefore, the dentinal surface will be more difficult to dry and the adaptation to at least resinous materials is reduced. A dentinal surface with expanded dentine channels might result in an bacterial invasion in the dentine channels in case an infection should occur later.
Now, it has been found that the smear layer can be removed effectively from the dentinal surface by means of a cleaning agent which contains as active substituent an invert soap and an ampholytic tenside together with minor amounts of complex forming agents.
In the cleaning agent for dentinal surfaces according to the invention 10-90 parts by weight of an invert soap comprising a compound having the formula: ##STR1## wherein R.sub.3 and R.sub.7 independent of each other or loweralkyl having 1-4 carbon atoms, both preferably being methyl, R.sub.6 is alkyl having in average 8-16 carbon atoms and Hal is halogen, preferably chlorine, but also fluorine, bromine or iodine, are in combination with 90-10 parts by weight of an ampholytic (amphoteric tenside) comprising a compound having the formula ##STR2## wherein R is the acyl radical of a fatty acid with 11-19 carbon atoms, R.sub.1 is CH.sub.2.COOM or M, Z is --COOM, --CH.sub.2.COOM or ##STR3## and M is an alkali metal, hydrogen or an organic base, or comprising a compound having the formula: ##STR4## wherein R.sub.2 is an alkyl group, preferably having 12-18 carbon atoms in average, or an alkylamino ethyl or alkylamino propyl radical having 8-18 carbon atoms or an acylaminoethyl or an acylaminopropyl radical, the acyl radical of which has in average 12-18 carbon atoms, and wherein R.sub.4 and R.sub.5 either both are methyl groups or wherein R.sub.4 is hydrogen and R.sub.5 is an electron pair. A complexing agent in minor amounts is always present. The complexing agent is a sequestering agent of aminocarboxylic acid type and the ratio between the amounts of invert soap and ampholytic tenside to complexing agent is preferably 100:1-1:100.
As is clear from the above the invert soaps are quaternary ammonium compounds. They have been used for a long time as disinfection agents; they are surface active and have a dirt dissolving ability.
The ampholytic tensides, e.g. of the type dicarboxylated imidazolines, have been used in shampooing agents, but also in deodorizing agents together with chlorohexidine. They have also been used as ampholytes in rust removers and metal cleaning agents.
The complex forming agents (the complexing agents, sequestering agents) are inter alia used analytically for forming complexes of metals, such as calcium.
The ampholytic (amphoteric) tenside can preferably be a tenside in the following groups of tensides: ##STR5## wherein R is the acyl radical of a fatty acid with, on an average, 11-19 carbon atoms, conveniently 13-17 carbon atoms, preferably 14-16 carbon atoms,
REFERENCES:
patent: 3849548 (1974-11-01), Grand
patent: 4051234 (1977-09-01), Gieske et al.
Dental Therapeutics AB
Rose Shep K.
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