Clean, High-yield preparation of S,S and R,S amino acid...

Details Clean, High-yield preparation of S,S and R,S amino acid... Clean, High-yield preparation of S,S and R,S amino acid...

2007-12-18

2007-12-18

Solola, Taofiq (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

Reexamination Certificate

active

11081106

ABSTRACT:
The present invention provides compounds and methods that can be used to convert the intermmediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

REFERENCES:
patent: 5684176 (1997-11-01), Hilpert
patent: 5817778 (1998-10-01), Archibald et al.
patent: 5847144 (1998-12-01), Hilpert
patent: 5854405 (1998-12-01), Archibald et al.
Barluenga et al.,J. Org. Chem., 62:4974-5977 (1997).
Barrish et al.,J. Med. Chem., 37(12):1758-1768 (1994).
Beaulieu et al.,J. Org. Chem., 63:3440-3448 (1997).
Chen et al.,J. Med. Chem., 39:1991-2007 (1998).
Dufour et al.,J. Chem. Soc. Perkin Trans. I, 1895-1899 (1986).
Ghosh et al.,J. Org. Chem., 62:6080-6082 (1997).
Liu et al.,Org. Proc. Res. Dev., 1:45-54 (1997).
Luly et al.,J. Org. Chem., 52:1487-1492 (1987).
Parkes et al.,J. Org. Chem., 59:3656-3664 (1994).
Raddatz et al.,J. Med. Chem., 34(11)3287-3280 (1991).
Shaw,Methods in Enzymology, 11:677-686 (1987).
Shibata et al.,Chem. Pharm. Bull., 46(4):733-735 (1998).

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