Clay magnetic resonance contrast agents for gastrointestinal com

Details Clay magnetic resonance contrast agents for gastrointestinal com Clay magnetic resonance contrast agents for gastrointestinal com

1987-11-19

1990-05-22

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, A61K 4900, G01N 2400

Patent

active

049276247

ABSTRACT:
Contrast medium compositions for delineation of bowel during magnetic resonance imaging (MRI) of the abdomen are provided for oral or rectal administration. The compositions consist of aqueous suspensions of clay in finely-divided particles which expose a large surface area to the suspending water and impose a condition of dynamic anisotropy upon the adjacent water, resulting in reduction predominantly in the transverse relaxation time of the water and subsequent loss of signal from the bowel lumen.

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