Clavulone derivatives, process for preparing the same, and use o

Details Clavulone derivatives, process for preparing the same, and use o Clavulone derivatives, process for preparing the same, and use o

1983-09-23

1985-12-24

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560121, C07C 69732, C07C 69738, A61K 31215

Patent

active

045607036

ABSTRACT:
Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.

REFERENCES:
Iguchi et al., Tet. Letters, 24(41) 4433 (1983).
K. Kuchi et al., Tet. Letters 23(49) 5171 (1982).
Kobayashi et al., Tet. Letters 23(50) 5331 (1982).

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