Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1984-08-03
1986-10-21
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4351721, 435254, C12P 1718, C12N 1500, C12N 114
Patent
active
046185810
ABSTRACT:
The invention relates to a new microbiological process for the preparation of clavine alkaloids of the general formula (I), ##STR1## wherein R stands for hydroxymethyl or methyl group, by cultivation of a Claviceps fusiformis strain in liquid submerged culture medium containing sources of carbon, nitrogen, mineral salts and optionally other additives, under aerobic conditions, in which a Claviceps fusiformis variant strain deposited under No. 00211 is used as alkaloid-producing strain. The invention further relates to a biologically pure culture of the Claviceps fusiformis variant strain No. 00211 obtained in a process in which a Claviceps fusiformis strain No. 00164 is grown in a solid culture medium containing sources of carbon, nitrogen, mineral salts and agar as well as an additive promoting the formation of cytochrome P-450, followed by the selective isolation of the new strain No. 00211.
REFERENCES:
patent: 3884762 (1975-05-01), Wack et al.
Turner et al., Fungal Metabolites II, Academic Press, p. 400, (1983).
Kordik Gabriella
Trinn Maria
Udvardy-Nagy nee Cserey Pechaany Eva
Vida Zsuzsanna
Zsoka nee Somkuti Rzsebet
Dubno Herbert
Richter Gedeon Vegyeszeti Gyar Rt.
Ross Karl F.
Tanenholtz Alvin E.
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