Clavanins

Details Clavanins Clavanins

1997-02-28

2000-03-21

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530326, C07K 1400, A61K 3702

Patent

active

060402938

ABSTRACT:
Novel microbial peptides called clavanins are of the formula

REFERENCES:
Cornelissen, B. J. C. et al., "Strategies for Control of Fungal Diseases with Transgenic Plants," Plant Physiol 101:709-712 (1993).
Bensch, K. W. et al., "hBD-1: a novel .beta.-defensin from human plasma," Febs Lett 368:331 (1995).
Christensen, B. et al., "Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes," Proc Natl Acad Sci USA 85:5072 (1988).
Diamond, G. et al., "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA," Proc Natl Acad Sci USA 88:3952 (1991).
Duclohier, H. et al., "Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayers," Biophys J 56:1017 (1989).
Harwig, S. S. L. et al., "Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes," Febs Lett 342:281 (1994).
Jones, D. E. et al., "Paneth Cells of the Human Small Intestine Express and Antimicrobial Peptide Gene," J Biol Chem 267:23216 (1992).
Kokryakov, V. N. et al., "Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins," Febs Lett 231 (1993).
Lehrer, R. I. et al., "Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells," Ann Rev Immunol 11:105 (1992).
Nakamura, T. et al., "Tachyplesin, a Class of Antimicrobial Peptide from the Hemocytes of the Horseshoe Crab (Tachypleus tridentatus)," J Biol Chem 263:16709-16713 (1988).
Patterson-Delafield, J. et al., "Microbial Cationic Proteins in Rabbit Alveolar Macrophages: a Potential Host Defense Mechanism," Infect Immun 30:180 (1980).
Schonwetter, B. S. et al., "Epithelial Antibiotics Induced at Sites of Inflammation," Science 267:1645 (1995).
Selsted, M. E. et al., "Purification, Primary Structures, and Antibacterial Activities of .beta.-Defensins, a New Family of Antimicrobia Peptides from Bovine Neutrophils," J. Biol Chem 268:6641.
Terry, A. S. et al., "The cDNA Sequence Coding for Prepro-PGS (Prepro-magainins) and Aspects of the Processing of This Prepro-polypeptide," J Biol Chem 263:5745 (1988).
Zasloff, M. et al., "Antimicrobial activity of synthetic magainin peptides and several analogues," Proc Natl Acad Sci USA 85:910 (1988).
Zasloff, M., "Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor," Proc Natl Acad Sci USA 84:5449 (1987).

Affiliated with

Also associated with

Rating

Clavanins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Clavanins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Clavanins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-730443