Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1990-12-26
1992-07-14
Elmore, Carolyn
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435189, 435886, C12N 902, C12P 1718
Patent
active
051302411
ABSTRACT:
A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid.
A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclisation, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.
REFERENCES:
patent: 3862008 (1975-01-01), Hamill et al.
patent: 4072569 (1978-02-01), Box
patent: 4078067 (1979-03-01), Christensen et al.
patent: 4110165 (1978-08-01), Cole et al.
patent: 4652560 (1987-03-01), Clarke et al.
Baggaley Keith H.
Elson Stephen W.
Woroniecki Stefan R.
Beecham Group plc
Elmore Carolyn
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