Claudin polypeptides, polynucleotides, and methods of making...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C530S350000, C435S069100

Reexamination Certificate

active

10965972

ABSTRACT:
This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify agents that alter Claudin polypeptide activities.

REFERENCES:
patent: 2004/0219521 (2004-11-01), Tang et al.
patent: WO 00/26360 (2000-05-01), None
patent: WO 02/14499 (2002-02-01), None
patent: WO 02/099062 (2002-12-01), None
patent: WO 03/008553 (2003-01-01), None
patent: WO 03/023013 (2003-03-01), None
STIC seqeunce search alignment data, protein search using sw model, Run on May 1, 2006, Title 10965972-6, pp. 1-3.
Database NCBI Sequence Viewer, AN:AAH16047, ‘National Institutes of Health, Mammalian Gene Collection (MGC), Cancer Genomics Office, National Cancer Institute’, Gene Sequence, Oct. 22, 2001.
Katoh and Katoh, “CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of the CLAUDIN gene family,”Int J Mol Med 11(6):683-689, Jun. 2003.
Morita et al.:“Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands” Proc. Natl. Acad. Sci USA, 96:511-516; 1999.
EMBL Database Accession No. AK009330, Feb. 8, 2001.
EMBL Database Accession No. BM821052, Mar. 10, 2002.
EMBL Database Accession No. BC016047, Oct. 26, 2001.
Partial European Search Report, EP 03731300, Aug. 26, 2005.

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