Image analysis – Applications – Biomedical applications
Reexamination Certificate
2005-04-05
2005-04-05
Mehta, Bhavesh M. (Department: 2625)
Image analysis
Applications
Biomedical applications
C435S006120, C382S133000
Reexamination Certificate
active
06876760
ABSTRACT:
Image analysis methods analyze images of cells and place the cells in particular cell cycle phases based upon certain features extracted from the images. The methods can also quantify the total amount of DNA in a cell based on specific features such as fluorescence intensity from fluorescent molecules that bind to DNA. Further, the methods can characterize a cell as mitotic or interphase based on chosen parameters such as the variance in intensity observed in a cell image and/or the size of a region containing DNA. In one example, image analysis methods can classify the cell into one of the following five phases: G1, S, G2, telophase, and an early stage mitotic phase comprised of prophase, metaphase, and anaphase.
REFERENCES:
patent: 4818710 (1989-04-01), Sutherland et al.
patent: 4922092 (1990-05-01), Rushbrooke et al.
patent: 5016283 (1991-05-01), Bacus et al.
patent: RE34214 (1993-04-01), Carlsson et al.
patent: 5281517 (1994-01-01), Bacus et al.
patent: 5287272 (1994-02-01), Rutenberg et al.
patent: 5326691 (1994-07-01), Hozier
patent: 5355215 (1994-10-01), Schroeder et al.
patent: 5526258 (1996-06-01), Bacus
patent: 5710022 (1998-01-01), Zhu et al.
patent: 5733721 (1998-03-01), Hemstreet, III et al.
patent: 5768412 (1998-06-01), Mitsuyama et al.
patent: 5777888 (1998-07-01), Rine et al.
patent: 5893095 (1999-04-01), Jain et al.
patent: 5962520 (1999-10-01), Smith et al.
patent: 5985549 (1999-11-01), Singer et al.
patent: 6078681 (2000-06-01), Silver
patent: 6083763 (2000-07-01), Balch
patent: 6146830 (2000-11-01), Friend et al.
patent: 6169816 (2001-01-01), Ravkin
patent: 6222093 (2001-04-01), Marton et al.
patent: 6345115 (2002-02-01), Ramm et al.
patent: 6615141 (2003-09-01), Sabry et al.
patent: 6658143 (2003-12-01), Hansen et al.
patent: 0317139 (1988-04-01), None
patent: WO 9321511 (1993-10-01), None
patent: WO 9411841 (1994-05-01), None
patent: WO9522749 (1995-08-01), None
patent: WO 9609605 (1996-03-01), None
patent: WO 9743732 (1997-11-01), None
patent: WO 9905323 (1999-02-01), None
patent: WO 0065472 (2000-11-01), None
patent: WO 0070528 (2000-11-01), None
Russ, J.C., “The Image Processing Handbook,” Second Edition, Boca Raton: CRC Press, 1995, pp. 169-474 and 457-461.
Lu et al., “Hierarchical Shape Recognition Using Polygon Approximation and Dynamic Alignment,” IEEE Paper CH2561-9, vol. 2, pp. 976-979, 1988.
Ravi Kapur, et al., “Design and Fabrication of Spatially Controlled Miniaturized Organ Systems From Stem Cells”, U.S. Provisional Patent Application No.: 60/127,339, Filed Apr. 1, 1999, 21 pages.
Terri Adams, et al., “Cell Patterning on Glass and Polymeric Substrates”, U.S. Provisional Patent Application No.: 60/138,119, filed Jun. 7, 1999, 17 pages.
Uria JA, Stahle-Backdahl M, Seiki M, Fueyo A, Lopez-Otin C, “Regulation of Collagenase-3 Expression in Human Breast Carcinomas in Mediated by Stromal-Epithelial Cell Interactions”, Cancer Res Nov. 1, 1997;57 (21):4882-8, Abstract.
“An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in Vitro,”Pharmaceutical Research, vol. 13, No. 1, pp. 23-27, 1996.
Sunblad et al., “The use of image analysis and automation for measuring mitotic index in apical confier meristems”, © Oxford University Press 1998, Journal of Experimental Botany, vol. 49, No. 327, pp. 1749-1756.
Cseke, I., “A Fast Segmentation Scheme for White Blood Cell Images” (1992) IEEE, pp. 530-533.
Serbouti, S., et al., “Image Segmentation and Classification Methods to Detect Leukemias”, (1991) Annual Int'l Conf. of IEEE Eng. In Medicine & Biology Soc., vol. 13, No. 1, pp. 0260-0261.
Hofland et al., “Role of Tumor-Derived Fibroblasts in the Growth of Primary Cultures of Human Breast-Cancer Cells: Effects of Epidermal Growth Factor an the Somatostatin Analogue Octreotide”, 1995, Int. J. Cancer: 60, 93-93.
Stearns et al., Interleukin 10 (IL-10) Inhibition of Primary Human Prostate Cell-induced Angiogenesis: IL-10 Stimulation of Tissue Inhibitor of Metalloproteinase-1 and Inhibition of Matrix Metalloproteinase (MMP)-2/MMP-9 Secretion, 1999, Clin. Can. Res. 5:189-96.
Takayama et al., “Patterning cells and their environments using multiple laminar fluid flows in capillary networks”, Proc. Natl., Acad. Sci. Vol. 96, pp. 5545-5548, May 1999.
U.S. Provisional application No. 60/127,339, Kapur et al., filed Apr. 1, 1999.
U.S. Provisional application No. 60/138,119, Adams et al., filed Jun. 7, 1999.
Hartwell et al., “Integrating Genetic Approaches into the Discovery of Anticancer Drugs”, Science, vol. 278, Nov. 7, 1997, pp. 1064-1068, XP002916842.
Ng et al., “Evaluating Multi-Dimensional Indexing Structures for Images Transformed by Principal Component Analysis”, Dept. of Computer Science, University of British Colombia, Vancouver, B.C. V6T 1Z4, Canada, Feb. 1, 1996, XP000642562.
Boland et al. “Automated Recognition of Patterns Characterisitc of Subcellular Structures in Fluorescence Microscopy Images”, Wiley-Liss, Inc., pp. 366-375, Cytometry 33:366-375 (1998).
Coleman Daniel A.
Vaisberg Eugeni A.
Beyer Weaver & Thomas LLP
Cytokinetics Inc.
Mehta Bhavesh M.
Tabatabai Abolfazl
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