Class of spiro-linked pyrrolidine-2,5-diones

Details Class of spiro-linked pyrrolidine-2,5-diones Class of spiro-linked pyrrolidine-2,5-diones

1984-12-24

1986-06-03

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 70, 546 15, C07D49820, C07D51320, C07D48720

Patent

active

045930929

ABSTRACT:
The invention provides a novel spiro-linked pyrrolidine-2,5-dione of the formula; ##STR1## wherein X.sub.1 and X.sub.2 each independently represent a hydrogen, a halogen atom, a lower alkyl or lower alkoxy group; Y is a methylene group, oxygen or sulfur atom; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represent a hydrogen atom, a lower alkyl group or forming a benzene ring together with their adjacent carbon atoms; the base salts thereof with pharmaceutically acceptable cations, and processes for their manufactures.
The compounds of formula [I] useful as aldose reductase inhibitors and as therapeutic agents for treatment of chronic diabetic complications are also disclosed.

REFERENCES:
patent: 4478847 (1984-10-01), Brittain et al.
patent: 4503066 (1985-03-01), Brittain et al.
Sarges, Chemical Abstracts, vol. 91 (1979) 20510y.
Sarges, Chemical Abstracts, vol. 92 (1980) 94401f.

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